董宇平+孫景先+王博+佟斌+張關(guān)心

摘 要：該研究通過AIE小分子/高分子的官能化，形成基于AIE原理的化學(xué)與生物檢測技術(shù)，觀察到修飾后的AIE分子對蛋白質(zhì)、酶、DNA、RNA等生物分子的特異響應(yīng)，實現(xiàn)了深紅/近紅外熒光的AIE材料在活性細胞與生物體內(nèi)的應(yīng)用，同時開展了AIE材料新結(jié)構(gòu)的開發(fā)以及應(yīng)用領(lǐng)域的擴展研究工作。

關(guān)鍵詞：聚集誘導(dǎo)發(fā)光 化學(xué)傳感器 生物傳感器

Abstract：In this year， we achieved the following progresses：（1）the introduction of the functional groups into AIE compounds；（2）the fabrication of novel AIE system with the mechanochromic properties；（3）the application of AIE compounds for studying the motions of polymeric chains；（4）the application of AIE compounds as biosensors for detection of proteins， enzyme， DNA， RNA and etc.；（5）the application of carmine/NIR AIE compounds for active cells and biosystems. We published 14 peer-reviewed papers and wrote 3 chapters for a Wiley book “Aggregation-Induced Emission”. We gave 3 invited talks on international conference. 4 PhD and 6 MS students graduated.

Key Words：Aggregated-Induced emission； Chemosensors； Biosensors

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