Jisuikang, a Chinese herbal formula, increases neurotrophic factor expression and promotes the recovery of neurological function after spinal cord injury
2017-10-11 02:21:15YangGuoYongMaYalanPanSuyangZhengJianweiWangGuichengHuang
中國神經(jīng)再生研究(英文版) 2017年9期
Yang Guo, Yong Ma, Ya-lan Pan Su-yang Zheng Jian-wei Wang, Gui-cheng Huang
1 Institute of Traumatology & Orthopedics and Laboratory of New Techniques of Restoration & Reconstruction of Orthopedics and Traumatology,Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
2 Department of Traumatology & Orthopedics, Af filiated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
3 Department of Traumatology & Orthopedics, Wuxi Hospital of Traditional Chinese Medicine Af filiated to Nanjing University of Chinese Medicine, Wuxi, Jiangsu Province, China
RESEARCH ARTICLE
Jisuikang, a Chinese herbal formula, increases neurotrophic factor expression and promotes the recovery of neurological function after spinal cord injury
Yang Guo1,#, Yong Ma1,2,#, Ya-lan Pan1, Su-yang Zheng1, Jian-wei Wang3, Gui-cheng Huang1,＊
1 Institute of Traumatology & Orthopedics and Laboratory of New Techniques of Restoration & Reconstruction of Orthopedics and Traumatology,Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
2 Department of Traumatology & Orthopedics, Af filiated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
3 Department of Traumatology & Orthopedics, Wuxi Hospital of Traditional Chinese Medicine Af filiated to Nanjing University of Chinese Medicine, Wuxi, Jiangsu Province, China
Graphical Abstract
Jisuikang, a Chinese herb formula, can upregulate the expression of brain-derived neurotrophic factor(BDNF) and nerve growth factor (NGF) for a long time after spinal cord injury
Abstract
Te Chinese medicine compound,Jisuikang, can promote recovery of neurological function by inhibiting lipid peroxidation, scavenging oxygen free radicals, and effectively improving the local microenvironment after spinal cord injury. However, the mechanism remains unclear. Tus, we established a rat model of acute spinal cord injury using a modified version of Allen’s method.Jisuikang(50, 25, and 12.5 g/kg/d) and prednisolone were administered 30 minutes after anesthesia. Basso, Beattie, and Bresnahan locomotor scale scores and the oblique board test showed improved motor function recovery in the prednisone group and moderate-doseJisuikanggroup compared with the other groups at 3–7 days post-injury. Te rats in the moderate-doseJisuikanggroup recovered best at 14 days post-injury. Hematoxylin-eosin staining and transmission electron microscopy showed that the survival rate of neurons in treatment groups increased after 3–7 days
- 中國神經(jīng)再生研究(英文版)的其它文章
- Unusual neural tract between injured fornix and pedunculopontine nucleus in a patient with traumatic brain injury
- Structure and function of the contactin-associated protein family in myelinated axons and their relationship with nerve diseases
- Adipose-derived mesenchymal stem cells accelerate nerve regeneration and functional recovery in a rat model of recurrent laryngeal nerve injury
- Phenotypic changes of Schwann cells on the proximal stump of injured peripheral nerve during repair using small gap conduit tube
- Scaffoldless tissue-engineered nerve conduit promotes peripheral nerve regeneration and functional recovery after tibial nerve injury in rats
- Methotrexate combined with methylprednisolone for the recovery of motor function and differential gene expression in rats with spinal cord injury