遺傳 2020年 第42卷 總目次

第1期

三維基因組專欄

染色質(zhì)構象與基因功能……………………………………………………………………黃其通，李清，張玉波(1)

CRISPR/Cas9基因編輯在三維基因組研究中的應用……………………………………………………………………劉沛峰，吳強(18)

細胞終末分化過程中三維基因組結(jié)構與功能調(diào)控的分子機制……………………………………………………………………楊科，薛征，呂湘(32)

生物大分子“液–液相分離”調(diào)控染色質(zhì)三維空間結(jié)構和功能……………………………………………………………………高曉萌，張治華(45)

Cohesin結(jié)構及功能研究進展……………………………………………………………………張雨，方玉達(57)

植物三維染色質(zhì)構型研究進展……………………………………………………………………董芊里，王金賓，李曉寵，宮磊(73)

基于生物信息學的Hi-C研究現(xiàn)狀與發(fā)展趨勢……………………………………………………………………呂紅強，郝樂樂，劉二虎，吳志芳，韓九強，劉源(87)

研究報告

DNMT3a通過提升基因內(nèi)部甲基化介導紫杉醇誘導的LINE-1異常表達……………………………………………………………………王昕源，張雨，楊楠，程禾，孫玉潔(100)

內(nèi)側(cè)前額葉皮質(zhì)DNA甲基化調(diào)控大鼠酒精相關行為……………………………………………………………………崔亨貞，孫蜜燭，王潤芝，李辰雨，黃予暄，黃秋菊，喬曉孟(112)

綜合信息

致謝2019年度審稿編委和審稿專家……………………………………………………………………(126)

第2期

綜 述

超家族轉(zhuǎn)座子研究進展……………………………………………………………………從春生，李玉斌(131)

基因組選擇在豬雜交育種中的應用……………………………………………………………………楊岸奇，陳斌，冉茂良，楊廣民，曾誠(145)

RNAi在抗蚊媒病毒感染中的研究進展……………………………………………………………………魏勇，何玉蘭，鄭學禮(153)

研究報告

突變導致先天性白內(nèi)障及其在晶狀體中的表達……………………………………………………………………于雅潔，邱峰，張新安(161)

脫發(fā)相關差異表達基因的生物信息學分析……………………………………………………………………向虹，陽小胡，艾亮霞，潘燕平，胡勇(172)

七鰓鰻分子鑒定、重組表達及免疫學研究……………………………………………………………………李歆，渠成名，韓英倫，劉欣，李慶偉(183)

互花米草NAC轉(zhuǎn)錄因子家族的鑒定與表達分析……………………………………………………………………王濤濤，楊勇，魏唯，林辰濤，馬留銀(194)

資源與平臺

2019新型冠狀病毒信息庫……………………………………………………………………趙文明，宋述慧，陳梅麗，鄒東，馬利娜，馬英克，李茹姣，郝麗麗，李翠萍，田東梅，唐碧霞，王彥青，朱軍偉，陳煥新，章張，薛勇彪，鮑一明(212)

遺傳學教學

通識教育中融入人類遺傳學的教學實踐……………………………………………………………………程漢華，周榮家(222)

綜合信息

作者須知……………………………………………………………………(230)

第3期

前沿聚焦

STEME系統(tǒng)：一種助力體內(nèi)定向進化的新工具……………………………………………………………………胡風越，王克劍(231)

綜 述

CRISPR-Cas基因編輯系統(tǒng)升級：聚焦Cas蛋白和PAM……………………………………………………………………唐連超，谷峰(236)

單細胞測序技術及其在乳腺癌研究中的應用……………………………………………………………………張強，顧明亮(250)

單細胞RNA測序技術在病毒研究中的應用……………………………………………………………………屈亮，李素，仇華吉(269)

寄主植物與病原菌免疫反應的分子遺傳基礎……………………………………………………………………楊德衛(wèi)，李生平，崔海濤，鄒聲浩，王偉(278)

研究報告

PAI-1過表達促進食管鱗癌細胞的侵襲和遷移……………………………………………………………………王迪，楊荔艷，劉奏，余竟，張敏杰，張鈺，蔡巖，徐昕，郝佳潔，王明榮(287)

74-plex SNPs復合檢測體系在中國人群中的族群推斷研究……………………………………………………………………劉楊，孫昌春，馬咪，王玲，趙雯婷，馬泉，季安全，劉京，李彩霞(296)

家兔前體脂肪細胞分化不同時期基因表達譜分析……………………………………………………………………杜坤，毛初陽，任安勇，吳雪梅，李慶玲，陳婷婷，陳仕毅，賴松家(309)

多組學關聯(lián)分析揭示表觀等位基因在擬南芥環(huán)境適應性進化中的作用及機制……………………………………………………………………梅志超，位竹君，于佳慧，冀鳳丹，解莉楠(321)

綜合信息

作者須知……………………………………………………………………(332)

第4期

綜 述

染色質(zhì)轉(zhuǎn)座酶可及性測序研究進展……………………………………………………………………吳杰，全建平，葉勇，吳珍芳，楊杰，楊明，鄭恩琴(333)

ATAC-seq在復雜疾病研究中的應用進展……………………………………………………………………陳敏，張崢，孟紫媛，張學軍(347)

NMD逃逸機制及其在疾病治療中的應用……………………………………………………………………程苗苗，曹延延(354)

數(shù)字PCR技術及其在檢測領域的應用……………………………………………………………………馮秀晶，易紅梅，任星旭，任佳麗，葛建镕，王鳳格(363)

研究報告

中國人群中抗結(jié)核藥物引發(fā)肝損傷的易感基因標記研究……………………………………………………………………周晨希，李沫，懷聰，賀林，秦勝營(374)

雙基因轉(zhuǎn)染山羊乳腺上皮細胞表達分析……………………………………………………………………宋紹征，于康英，張婷，陸睿，潘生強，周鳴鳴，成勇(380)

乏情和發(fā)情初產(chǎn)母豬下丘腦–垂體–卵巢軸中l(wèi)incRNAs表達譜比較分析……………………………………………………………………任巧玲，張家慶，陸東鋒，王璟，陳俊峰，馬強，白獻曉，郭紅霞，高彬文，邢寶松(388)

小擬南芥MKK基因家族全基因組鑒定及進化和表達分析……………………………………………………………………李曉翠，康凱程，黃先忠，范永斌，宋苗苗，黃韻杰，丁佳佳(403)

綜合信息

作者須知……………………………………………………………………(422)

第5期

綜 述

環(huán)狀RNA翻譯能力研究進展……………………………………………………………………鄭帥龍，李利，張紅平(423)

基于CRISPR/Cas9系統(tǒng)在全基因組范圍內(nèi)篩選功能基因及調(diào)控元件研究進展……………………………………………………………………劉思遠，易國強，唐中林，陳斌(435)

Schlafen家族蛋白在腫瘤和病毒感染中的研究進展……………………………………………………………………陳淑敏，馬鈴，岑山(444)

代謝組學技術發(fā)展及其在農(nóng)業(yè)動植物研究中的應用……………………………………………………………………田菁，王宇哲，閆世雄，孫帥，賈俊靜，胡曉湘(452)

植物單倍體誘導技術發(fā)展與創(chuàng)新……………………………………………………………………陳海強，劉會云，王軻，張雙喜，葉興國(466)

研究報告

2型糖尿病易感基因SNP位點對生活方式干預降低血糖應答效果的修飾效應……………………………………………………………………王玉琢，張一鳴，董曉蓮，王學才，朱建福，王娜，江峰，陳躍，姜慶五，付朝偉(483)

利用SNP芯片信息評估新疆近交?；蚪M純合度……………………………………………………………………師睿，張毅，王雅春，黃濤，盧國昌，岳濤，盧振西，黃錫霞，衛(wèi)新璞，馮書堂，陳軍，烏蘭·卡格德爾，茹先古麗·阿不力孜，努爾胡馬爾·木合塔爾(493)

水稻典型品種日本晴和IR24根系微生物組的解析……………………………………………………………………胡雅麗，戴睿，劉永鑫，張婧贏，胡斌，儲成才，袁懷波，白洋(506)

第6期

前沿聚焦

Prime editing引導植物基因組精確編輯新局面……………………………………………………………………秦瑞英，魏鵬程(519)

綜 述

精子尾部發(fā)育相關蛋白研究進展……………………………………………………………………鐘亞楠，牛長敏，夏蒙蒙，鄭英(524)

組蛋白去乙?；冈谡{(diào)節(jié)心肌肥大過程中的作用機制……………………………………………………………………任戀，吳秀山，李永青(536)

泛素化途徑在奶牛乳脂生成過程中的調(diào)控作用……………………………………………………………………劉莉莉，郭愛偉，李青青，吳培福，楊亞晉，陳粉粉，李素華，郭盤江，張勤(548)

CRISPR/Cas核糖核蛋白介導的植物基因組編輯……………………………………………………………………李霞，施皖，耿立召，許建平(556)

研究報告

中國西南地區(qū)藏族人群遺傳亞結(jié)構研究……………………………………………………………………王小娟，錢恩芳，李悅，宋正陽，趙慧，謝何鑫，李彩霞，黃江，江麗(565)

基于結(jié)直腸癌細胞系MIC50相關基因?qū)Φ幕A耐藥評分模型構建……………………………………………………………………陳湖星，徐蕾，李靜，郭政，敖露(577)

利用Trim-Away技術降低人胰島淀粉樣多肽在大鼠胰島素瘤細胞中的毒性……………………………………………………………………龔葭薇，孔德麟，楊琳，聶玉哲，梁洋，滕春波(586)

技術與方法

基于體細胞突變數(shù)據(jù)庫篩選免疫原性結(jié)直腸癌高頻新抗原的方法……………………………………………………………………秦麗麗，李毅堅，梁兆端，陳蕾，李文慧，陳超，黃亞靈，張樂，劉松明，邱思，葛玉萍，彭文婷，林欣欣，張秀清，董旋，李波(599)

第7期

特邀綜述

翻譯延伸的順式調(diào)控機理與生物學效應……………………………………………………………………肇濤瀾，張碩，錢文峰(613)

綜 述

DNA羥甲基化調(diào)控動脈粥樣硬化的研究進展……………………………………………………………………胡穎楚，胡豪暢，林少沂，陳曉敏(632)

提高CRISPR/Cas9介導的動物基因組精確插入效率研究進展……………………………………………………………………李國玲，楊善欣，吳珍芳，張獻偉(641)

CRISPR/Cas9系統(tǒng)在林木基因編輯中的應用……………………………………………………………………陳贏男，陸靜(657)

研究報告

SLFN14抗LINE-1分子機制研究……………………………………………………………………毛洋，丁寄葳，陳淑敏，岑山，李曉宇(669)

中國漢族人群臉部特征相關SNP位點研究……………………………………………………………………劉明，李祎，楊亞芳，晏于文，劉凡，李彩霞，曾發(fā)明，趙雯婷(680)

基于序列相似性和Z曲線方法重注釋原核生物蛋白編碼基因……………………………………………………………………劉碩，曾志，曾凡才，杜萌澤(691)

技術與方法

基于單細胞靶向測序探究基因堿基突變的方法……………………………………………………………………趙利楠，王娜，楊國良，蘇現(xiàn)斌，韓澤廣(703)

第8期

綜 述

G蛋白偶聯(lián)受體相關分選蛋白功能特征與相關疾病研究進展……………………………………………………………………張敏，梁麗鴻，魯雅潔，曹新(713)

斑馬魚血液疾病模型及應用……………………………………………………………………郭佳妮，劉帆，王璐(725)

激素調(diào)控植物成花機理研究進展……………………………………………………………………鄒禮平，潘鋮，王夢馨，崔林，韓寶瑜(739)

假單胞菌噬菌體基因組學研究進展……………………………………………………………………徐志偉，魏云林，季秀玲(752)

研究報告

RFX5調(diào)控原鈣粘蛋白基因簇的表達……………………………………………………………………王娜，甲芝蓮，吳強(760)

DNA甲基化驅(qū)動的轉(zhuǎn)錄表達特征作為肝癌預后預測標志物的價值……………………………………………………………………駱紅波，曹鵬博，周鋼橋(775)

大豆E2泛素結(jié)合酶基因的克隆及在擬南芥中的異源表達……………………………………………………………………毛卓卓，宮宇，史貴霞，李亞麗，喻德躍，黃方(788)

資源與平臺

CNGBdb：國家基因庫生命大數(shù)據(jù)平臺……………………………………………………………………陳鳳珍，游麗金，楊帆王麗娜，郭學芹，高飛，華聰，談聰，方林，單日強，曾文君，王博，王韌，徐訊，魏曉鋒(799)

遺傳學教學

形成性評價與教學反饋在醫(yī)學遺傳學PBL教學中的應用……………………………………………………………………王濤，梁亮，鄭敏化(810)

第9期

綜 述

增強子的鑒定及其在腫瘤研究中的應用……………………………………………………………………劉倩，李春燕(817)

慢性阻塞性肺疾病全基因組關聯(lián)研究進展……………………………………………………………………錢國清(832)

七鰓鰻：生物進化和疾病研究的重要模式動物……………………………………………………………………朱醫(yī)高，李軍，逄越，李慶偉(847)

植物激素水楊酸生物合成和信號轉(zhuǎn)導研究進展……………………………………………………………………谷曉勇，劉揚，劉利靜(858)

用于臨床新型冠狀病毒核酸檢測的分子診斷新技術……………………………………………………………………謝春梅，武海萍，馬雪萍，周國華(870)

研究報告

端粒長度與2型糖尿?。好系聽栯S機化研究與多基因風險評分分析……………………………………………………………………曹嵐，李志強，師詠勇，劉赟(882)

骨質(zhì)疏松易感SNP rs4325274通過增強子遠程調(diào)控基因的功能機制研究……………………………………………………………………妥曉梅，朱東麗，陳曉峰，榮譽，郭燕，楊鐵林(889)

豬耳成纖維細胞轉(zhuǎn)錄組異質(zhì)性及對核移植胚胎發(fā)育的潛在影響……………………………………………………………………周俊，趙成成，吳霄，石俊松，周榮，吳珍芳，李紫聰(898)

遺傳學教學

普通小麥相關研究進展在遺傳學理論教學中的應用……………………………………………………………………趙娜，亓寶，董芊里，王曉麗(916)

第10期

編委推薦(927)

綜 述

真核生物起源研究進展……………………………………………………………………高志偉，王龍(929)

基于CRISPR/Cas9技術的β-地中海貧血和血友病基因治療研究進展……………………………………………………………………鮑莉雯，周一葉，曾凡一(949)

PCSK9降解低密度脂蛋白受體分子機制研究進展……………………………………………………………………吳玉嫻，王琰(965)

動物骨代謝相關信號通路研究進展……………………………………………………………………趙凈穎，段小花，王秋婷，黃英，賈俊靜，豆騰飛(979)

體細胞克隆豬發(fā)育異常研究進展……………………………………………………………………敖政，陳祥，吳珍芳，李紫聰(993)

研究報告

早期停育胚胎的滋養(yǎng)層細胞相關基因與特征分析……………………………………………………………………張悅，馮穎，馬芳(1004)

利用CRISPR/Cas9 AAV系統(tǒng)構建紋狀體基因敲除小鼠模型……………………………………………………………………林珉婷，賴璐璐，趙淼，林必瑋，姚香平(1017)

技術與方法

基于核質(zhì)遺傳原理建立多重PCR檢測方法鑒定阿膠中馬、驢源性成分及皮張種源……………………………………………………………………諶陽，王文君，付明，徐國強，周翔，劉榜(1028)

第11期

編委推薦(1037)

熱點追蹤

抑制膽固醇合成促進能量消耗并改善代謝綜合征……………………………………………………………………王琰(1039)

綜 述

誘導多能干細胞技術及其在疾病研究中的應用……………………………………………………………………蔡晨依，孟飛龍，饒琳，劉云玥，趙小立(1042)

miRNA與腎臟發(fā)育……………………………………………………………………趙曉琪，敖英，陳海云，汪暉(1062)

農(nóng)業(yè)動物干細胞研究進展……………………………………………………………………王冰源，牟玉蓮，李奎，劉志國(1073)

犏牛雄性不育的減數(shù)分裂基因表達與表觀遺傳調(diào)控研究進展……………………………………………………………………陳會友，張建敏，李柏森，鄧永琳，張龔煒(1081)

雙翅目昆蟲基因組研究進展……………………………………………………………………彭威，馮蒙潔，陳皓，韓寶瑜(1093)

研究報告

細胞凋亡反應中基因啟動子發(fā)揮增強子功能調(diào)節(jié)基因表達……………………………………………………………………秦中勇，石曉，曹平平，褚鷹，管蔚，楊楠，程禾，孫玉潔(1110)

基因在果蠅睪丸生殖細胞中的功能分析……………………………………………………………………陳萬銀，顏一丹，欒曉瑾，王敏，方杰(1122)

遺傳學教學

對分課堂下本科生醫(yī)學遺傳學自主學習能力的培養(yǎng)……………………………………………………………………楊榆玲，羅蘭，錢源，楊芳(1133)

綜合信息

2020年《遺傳》新一屆編委會第一次會議圓滿結(jié)束……………………………………………………………………(1140)

第12期

編委推薦……………………………………………………………………(1141)

綜 述

MNase-seq與核小體定占位研究……………………………………………………………………鄧瑋杭，李鑫輝(1143)

m6A修飾對中樞神經(jīng)系統(tǒng)功能及疾病的影響……………………………………………………………………史佳賓，王大勇，夏晴，高旭(1156)

精準調(diào)控CRISPR/Cas9基因編輯技術研究進展……………………………………………………………………曹俊霞，王友亮，王征旭(1168)

circRNA及其調(diào)控動物骨骼肌發(fā)育研究進展……………………………………………………………………鄭婷，甘麥鄰，沈林園，牛麗莉，郭宗義，王金勇，張順華，朱礪(1178)

研究報告

納米銀顆粒及納米二氧化鈦顆粒的體外遺傳毒性研究……………………………………………………………………朱海美，黃鵬程，趙田田，周長慧，李若婉，于春榮，陳志勇，顧林峰，常艷(1192)

RNA結(jié)合蛋白Roquin負調(diào)控STING依賴的果蠅天然免疫反應……………………………………………………………………杜倍倍，劉磊，朱洋洋(1201)

遺傳學教學

遺傳漂變教學方法芻議……………………………………………………………………王春明，林昌俊，馮虎元(1211)

科研進展

CRISPR-Cas9對人類線粒體基因組微同源區(qū)切割后產(chǎn)生新生變異……………………………………………………………………王邦，谷峰(1221)

HEREDITAS (Beijing)

YICHUAN

2020 Vol. 42

CONTENTS

No. 1

Special Section: 3D Genome

Linking chromatin conformation to gene function……………………………………………………………………Qitong Huang, Qing Li, Yubo Zhang(1)

Probing 3D genome by CRISPR/Cas9……………………………………………………………………Peifeng Liu, Qiang Wu(18)

Molecular mechanism of the 3D genome structure and function regulation during cell terminal differentiation……………………………………………………………………Ke Yang, Zheng Xue, Xiang Lv(32)

Three-dimensional structure and function of chromatin regulated by “l(fā)iquid-liquid phase separation” of biological macromolecules.……………………………………………………………………Xiaomeng Gao, Zhihua Zhang(45)

Progresses on the structure and function of cohesin……………………………………………………………………Yu Zhang, Yuda Fang(57)

Progresses in the plant 3D chromatin architecture……………………………………………………………………Qianli Dong, Jinbin Wang, Xiaochong Li, Lei Gong(73)

Current status and future perspectives in bioinformatical analysis of Hi-C data……………………………………………………………………Hongqiang Lyu, Lele Hao, Erhu Liu, Zhifang Wu, Jiuqiang Han, Yuan Liu(87)

Research Article

DNMT3a mediates paclitaxel-induced abnormal expression of LINE-1 by increasing the intragenic methylation…………………………………………………………………………………………………………………………………………Xinyuan Wang, Yu Zhang, Nan Yang, He Cheng, Yujie Sun(100)

DNA methylation in the medial prefrontal cortex regulates alcohol-related behavior in rats……………………………………………………………………Hengzhen Cui, Mizhu Sun, Runzhi Wang, Chenyu Li, Yuxuan Huang, Qiuju Huang, Xiaomeng Qiao(112)

No. 2

Review

Progress onsuperfamily……………………………………………………………………Chunsheng Cong, Yubin Li(131)

The application of genomic selection in pig cross breeding……………………………………………………………………Anqi Yang, Bin Chen, Maoliang Ran, Guangmin Yang, Cheng Zeng(145)

Research progress in RNA interference against the infection of mosquito-borne viruses……………………………………………………………………Yong Wei, Yulan He, Xueli Zheng(153)

Research Article

Studies of congenital cataract-relatedmutation and its expression in the lens……………………………………………………………………Yajie Yu, Feng Qiu, Xin-an Zhang(161)

Bioinformatics analysis of differentially expressed genes on alopecia……………………………………………………………………Hong Xiang, Xiaohu Yang, Liangxia Ai, Yanping Pan, Yong Hu(172)

Identification, recombinant expression and immunological study ofin Lampetra japonica……………………………………………………………………Xin Li, Chengming Qu, Yinglun Han, Xin Liu, Qingwei Li(183)

Identification and expression analyses of the NAC transcription factor family in……………………………………………………………………Taotao Wang, Yong Yang, Wei Wei, Chentao Lin, Liuyin Ma(194)

Resource and Platform

The 2019 novel coronavirus resource……………………………………………………………………Wenming Zhao, Shuhui Song, Meili Chen, Dong Zou, Lina Ma, Yingke Ma, Rujiao Li, Lili Hao, Cuiping Li, Dongmei Tian, Bixia Tang, Yanqing Wang, Junwei Zhu, Huanxin Chen, Zhang Zhang, Yongbiao Xue, Yiming Bao(212)

Genetics Teaching

Teaching practice in human genetics integrated into general education……………………………………………………………………Hanhua Cheng, Rongjia Zhou(222)

No. 3

Frontier Focus

The STEME system: a novel tool for directed evolution……………………………………………………………………Fengyue Hu, Kejian Wang(231)

Review

Next-generation CRISPR-Cas for genome editing: focusing on the Cas protein and PAM……………………………………………………………………Lianchao Tang, Feng Gu(236)

Single-cell sequencing and its application in breast cancer……………………………………………………………………Qiang Zhang, Mingliang Gu(250)

Applications of single-cell RNA sequencing in virology……………………………………………………………………Liang Qu, Su Li, Huaji Qiu(269)

Molecular genetic mechanisms of interaction between host plants and pathogens……………………………………………………………………Dewei Yang, Shengping Li, Haitao Cui, Shenghao Zou, Wei Wang(278)

Research Article

PAI-1 overexpression promotes invasion and migration of esophageal squamous carcinoma cells……………………………………………………………………Di Wang, Liyan Yang, Zou Liu, Jing Yu, Minjie Zhang, Yu Zhang, Yan Cai, Xin Xu, Jiajie Hao, Mingrong Wang(287)

The ancestry inference of Chinese populations using 74-plex SNPs system……………………………………………………………………Yang Liu, Changchun Sun, Mi Ma, Ling Wang, Wenting Zhao, Quan Ma, Anquan Ji, Jing Liu, Caixia Li(296)

Analysis of gene expression profiles at different stages during preadipocyte differentiation in rabbits……………………………………………………………………Kun Du, Chuyang Mao, Anyong Ren, Xuemei Wu, Qingling Li, Tingting Chen, Shiyi Chen, Songjia Lai(309)

Multi-omics association analysis revealed the role and mechanism of epialleles in environmental adaptive evolution of……………………………………………………………………Zhichao Mei, Zhujun Wei, Jiahui Yu, Fengdan Ji, Linan Xie(321)

No. 4

Review

Advances in assay for transposase-accessible chromatin with high-throughput sequencing……………………………………………………………………Jie Wu, Jianping Quan, Yong Ye, ZhenFang Wu, Jie Yang, Ming Yang, Enqin Zheng(333)

ATAC-seq and its applications in complex disease……………………………………………………………………Min Chen, Zheng Zhang, Ziyuan Meng, Xuejun Zhang(347)

The NMD escape mechanism and its application in disease therapy……………………………………………………………………Miaomiao Cheng, Yanyan Cao(354)

Digital PCR and its application in biological detection……………………………………………………………………Xiujing Feng, Hongmei Yi, Xingxu Ren, Jiali Ren, Jianrong Ge, Fengge Wang(363)

Research Article

Study on hereditary susceptibility genetic markers to anti-tuberculosis drug induced liver injury in Chinese population……………………………………………………………………Chenxi Zhou, Mo Li, Cong Huai, Lin He, Shengying Qin(374)

Expression analysis ofdouble genes in transfected goat mammary epithelial cells……………………………………………………………………Shaozheng Song, Kangying Yu, Ting Zhang, Rui Lu, Shengqiang Pan, Mingming Zhou, Yong Cheng(380)

Comparison and analysis of lincRNAs expression profile in the hypothalamic-pituitary-ovarian axis of anestrous and estrous primiparous sows……………………………………………………………………Qiaoling Ren, Jiaqing Zhang, Dongfeng Lu, Jing Wang, Junfeng Chen, Qiang Ma, Xianxiao Bai, Hongxiao Guo, Binwen Gao, Baosong Xing(388)

Genome-wide identification, phylogenetic analysis and expression profiling of the MKK gene family in……………………………………………………………………Xiaocui Li, Kaicheng Kang, Xianzhong Huang, Yongbin Fan, Miaomiao Song, Yunjie Huang, Jiajia Ding(403)

No. 5

Review

Progress on translation ability of circular RNA……………………………………………………………………Shuailong Zheng, Li Li, Hongping Zhang(423)

Progress on genome-wide CRISPR/Cas9 screening for functional genes and regulatory elements……………………………………………………………………Siyuan Liu, Guoqiang Yi, Zhonglin Tang, Bin Chen(435)

Progress of SLFN family proteins in tumor and virus infection……………………………………………………………………Shumin Chen, Ling Ma, Shan Cen(444)

Metabolomics technology and its applications in agricultural animal and plant research……………………………………………………………………Jing Tian, Yuzhe Wang, Shixiong Yan, Shuai Sun, Junjing Jia, Xiaoxiang Hu(452)

Development and innovation of haploid induction technologies in plants……………………………………………………………………Haiqiang Chen, Huiyun Liu, Ke Wang, Shuangxi Zhang, Xingguo Ye(466)

Research Article

Modification effects of T2DM-susceptible SNPs on the reduction of blood glucose in response to lifestyle interventions……………………………………………………………………Yuzhuo Wang, Yiming Zhang, Xiaolian Dong, Xuecai Wang, Jianfu Zhu, Na Wang, Feng Jiang, Yue Chen, Qingwu Jiang, Chaowei Fu(483)

The evaluation of genomic homozygosity for Xinjiang inbred population by SNP panels……………………………………………………………………Rui Shi, Yi Zhang, Yachun Wang, Tao Huang, Guochang Lu, Tao Yue, Zhenxi Lu, Xixia Huang, Xinpu Wei, Shutang Feng, Jun Chen, Wulan Kagedeer, Ruxianguli Abulizi, Nuerhumaer Muhetaer(493)

Analysis of rice root bacterial microbiota of Nipponbare and IR24……………………………………………………………………Yali Hu, Rui Dai, Yongxin Liu, Jingying Zhang, Bin Hu, Chengcai Chu, Huaibo Yuan, Yang Bai(506)

No. 6

Frontier Focus

Prime editing creates a novel dimension of plant precise genome editing……………………………………………………………………Ruiying Qin, Pengcheng Wei(519)

Review

Research progress of proteins related to sperm tail development……………………………………………………………………Yanan Zhong, Changmin Niu, Mengmeng Xia, Ying Zheng(524)

The mechanism underlying histone deacetylases regulating cardiac hypertrophy……………………………………………………………………Lian Ren, Xiushan Wu, Yongqing Li(536)

The regulation of ubiquitination in milk fat synthesis in bovine……………………………………………………………………Lili Liu, Aiwei Guo, Qingqing Li, Peifu Wu, Yajin Yang, Fenfen Chen, Suhua Li, Panjiang Guo, Qin Zhang(548)

Genome editing in plants directed by CRISPR/Cas ribonucleoprotein complexes……………………………………………………………………Xia Li, Wan Shi, Lizhao Geng, Jianping Xu(556)

Research Article

A genetic sub-structure study of the Tibetan population in Southwest China……………………………………………………………………Xiaojuan Wang, Enfang Qian, Yue Li, Zhengyang Song, Hui Zhao, Hexin Xie, Caixia Li, Jiang Huang, Li Jiang(565)

The development of a general drug resistance score model based on MIC50related genepairs in colorectal cancer cell lines……………………………………………………………………Huxing Chen, Lei Xu, Jing Li, Zheng Guo, Lu Ao(577)

Toxicity reduction of human islet amyloid polypeptide by Trim-Away technique in insulinoma cells……………………………………………………………………Jiawei Gong, Delin Kong, Lin Yang, Yuzhe Nie, Yang Liang, Chun-Bo Teng(586)

Technique and Method

A method of screening highly common neoantigens with immunogenicity in colorectal cancer based on public somatic mutation library……………………………………………………………………Lili Qin, Yijian Li, Zhaoduan Liang, Lei Chen, Wenhui Li, Chao Chen, Yaling Huang, Le Zhang, Songming Liu, Si Qiu, Yuping Ge, Wenting Peng, Xinxin Lin, Xiuqing Zhang, Xuan Dong, Bo Li(599)

No. 7

Invited Review

-regulatory mechanisms and biological effects of translation elongation……………………………………………………………………Taolan Zhao, Shuo Zhang, Wenfeng Qian(613)

Review

The role of DNA hydroxymethylation in the regulation of atherosclerosis……………………………………………………………………Yingchu Hu, Haochang Hu, Shaoyi Lin, Xiaomin Chen(632)

Recent developments in enhancing the efficiency of CRISPR/Cas9-mediated knock-in in animals……………………………………………………………………Guoling Li, Shanxin Yang, Zhenfang Wu, Xianwei Zhang(641)

Application of CRISPR/Cas9 mediated gene editing in trees……………………………………………………………………Yingnan Chen, Jing Lu(657)

Research Article

SLFN14 inhibits LINE-1 transposition activity……………………………………………………………………Yang Mao, Jiwei Ding, Minshu Chen, Shan Cen, Xiaoyu Li(669)

Human facial shape related SNP analysis in Han Chinese populations……………………………………………………………………Ming Liu, Yi Li, Yafang Yang, Yuwen Yan, Fan Liu, Caixia Li, Faming Zeng, Wenting Zhao(680)

Comprehensive re-annotation of protein-coding genes for prokaryotic genomes by Z-curve and similarity-based methods……………………………………………………………………Shuo Liu, Zhi Zeng, Fancai Zeng, Mengze Du(691)

Technique and Method

A method for reliable detection of genomic point mutations based on single-cell target-sequencing……………………………………………………………………Linan Zhao, Na Wang, Guoliang Yang, Xianbin Su, Zeguang Han(703)

No. 8

Review

G protein-coupled receptor-associated sorting proteins: function and relevant disorders……………………………………………………………………Min Zhang, Lihong Liang, Yajie Lu, Xin Cao(713)

Zebrafish blood disease models and applications……………………………………………………………………Jiani Guo, Fan Liu, Lu Wang(725)

Progress on the mechanism of hormones regulating plant flower formation……………………………………………………………………Liping Zou, Cheng Pan, Mengxin Wang, Lin Cui, Baoyu Han(739)

Progress on phage genomics ofspp.……………………………………………………………………Zhiwei Xu, Yunlin Wei, Xiuling Ji(752)

Research Article

RFX5 regulates gene expression of thecluster……………………………………………………………………Na Wang, Zhilian Jia, Qiang Wu(760)

Prognostic and predictive value of a DNA methylation-driven transcriptional signature in hepatocellular carcinoma……………………………………………………………………Hongbo Luo, Pengbo Cao, Gangqiao Zhou(775)

Cloning of the soybean E2 ubiquitin-conjugating enzymeand its expression in……………………………………………………………………Zhuozhuo Mao, Yu Gong, Guixia Shi, Yali Li, Deyue Yu, Fang Huang(788)

Resource and Platform

CNGBdb: China National GeneBank DataBase……………………………………………………………………Fengzhen Chen, Lijin You, Fan Yang, Lina Wang, Xueqin Guo, Fei Gao, Cong Hua, Cong Tan, Lin Fang, Riqiang Shan, Wenjun Zeng, Bo Wang, Ren Wang, Xun Xu, Xiaofeng Wei(799)

Genetics Teaching

Application of formative evaluation and teaching feedback in PBL teaching of Medical Genetics……………………………………………………………………Tao Wang, Liang Liang, Minhua Zheng(810)

No. 9

Review

The identification of enhancers and its application in cancer studies……………………………………………………………………Qian Liu, Chunyan Li(817)

Advances in genome-wide association study of chronic obstructive pulmonary disease……………………………………………………………………Guoqing Qian(832)

Lamprey: an important animal model of evolution and disease research……………………………………………………………………Yigao Zhu, Jun Li, Yue Pang, Qingwei Li(847)

Progress on the biosynthesis and signal transduction of phytohormone salicylic acid……………………………………………………………………Xiaoyong Gu, Yang Liu, Lijing Liu(858)

New molecular diagnostic technologies for clinical detection of SARS-CoV-2……………………………………………………………………Chunmei Xie, Haiping Wu, Xueping Ma, Guohua Zhou(870)

Research Article

Telomere length and type 2 diabetes: Mendelian randomization study and polygenic risk score analysis……………………………………………………………………Lan Cao, Zhiqiang Li, Yongyong Shi, Yun Liu(882)

The osteoporosis susceptible SNP rs4325274 remotely regulates the SOX6 gene through enhancers……………………………………………………………………Xiaomei Tuo, Dongli Zhu, Xiao feng Chen, Yu Rong, Yan Guo, Tie-Lin Yang(889)

Transcriptome heterogeneity of porcine ear fibroblast and its potential influence on embryo development in nuclear transplantation……………………………………………………………………Jun Zhou, Chengcheng Zhao, Xiao Wu, Junsong Shi, Rong Zhou, Zhenfang Wu, Zicong Li(898)

Genetics Teaching

The applications of research progress of common wheat in teaching genetics……………………………………………………………………Na Zhao, Bao Qi, Qianli Dong, Xiaoli Wang(916)

No. 10

Review

Progress in elucidating the origin of eukaryotes……………………………………………………………………Zhiwei Gao, Long Wang(929)

Advances in gene therapy for β-thalassemia and hemophilia based on the CRISPR/Cas9 technology……………………………………………………………………Liwen Bao, Yiye Zhou, Fanyi Zeng(949)

Progress on the molecular mechanisms of PCSK9-mediated degradation of low density lipoprotein receptor……………………………………………………………………Yuxian Wu, Yan Wang(965)

Progress on signal pathways related to bone metabolism in animals……………………………………………………………………Jingying Zhao, Xiaohua Duan, Qiuting Wang, Ying Huang, Junjing Jia, Tengfei Dou(979)

Progress on abnormal development of cloned pigs generated by somatic cell transfer nuclear……………………………………………………………………Zheng Ao, Xiang Chen, Zhenfang Wu, Zicong Li(993)

Research Article

Related genes and characteristic analysis of trophoblast cells during early embryo developmental cessation……………………………………………………………………Yue Zhang, Ying Feng, Fang Ma(1004)

Construction of a striatum-specificgene knockout mice model by CRISPR/Cas9 AAV system……………………………………………………………………Minting Lin, Lulu Lai, Miao Zhao, Biwei Lin, Xiangping Yao(1017)

Technique and Method

A multiplex PCR method based on nuclear and cytoplasmic inheritance to identify the horse and donkey-derived components ofand the hide……………………………………………………………………Yang Shen, Wenjun Wang, Ming Fu, Guoqiang Xu, Xiang Zhou, Bang Liu(1028)

No. 11

Review

Induced pluripotent stem cell technology and its application in disease research……………………………………………………………………Chenyi Cai, Feilong Meng, Lin Rao, Yunyue Liu, Xiaoli Zhao(1042)

The role of miRNA in kidney development……………………………………………………………………Xiaoqi Zhao, Ying Ao, Haiyun Chen, Hui Wang(1062)

Research progress of stem cells in agricultural animals……………………………………………………………………Bingyuan Wang, Yulian Mu, Kui Li, Zhiguo Liu(1073)

Progress on meiotic gene expression and epigenetic regulation of male sterility in Dzo cattle……………………………………………………………………Huiyou Chen, Jianmin Zhang, Baisen Li, Yonglin Deng, Gongwei Zhang(1081)

Progress on genome sequencing of Dipteran insects……………………………………………………………………Wei Peng, Mengjie Feng, Hao Chen, Baoyu Han(1093)

Research Article

Thepromoter could function as an active enhancer to regulate the expression ofin the apoptosis response ……………………………………………………………………Zhongyong Qin, Xiao Shi, Pingping Cao, Ying Chu, Wei Guan, Nan Yang, He Cheng, Yujie Sun(1110)

Functional analysis ofgene intestis……………………………………………………………………Wanyin Chen, Yidan Yan, Xiaojin Luan, Min Wang, Jie Fang(1122)

Genetics Teaching

Cultivation of undergraduates’ self-regulated learning ability in Medical Genetics based on PAD class……………………………………………………………………Yuling Yang, Lan Luo, Yuan Qian, Fang Yang(1133)

No. 12

Review

Resolving nucleosomal positioning and occupancy with MNase-seq……………………………………………………………………Weihang Deng, Xinhui Li(1143)

The effects of m6A modification in central nervous system function and disease……………………………………………………………………Jiabin Shi, Dayong Wang, Qing Xia, Xu Gao(1156)

Advances in precise regulation of CRISPR/Cas9 gene editing technology……………………………………………………………………Junxia Cao, Youliang Wang, Zhengxu Wang(1168)

circRNA on animal skeletal muscle development regulation……………………………………………………………………Ting Zheng, Mailin Gan, Linyuan Shen, Lili Niu, Zongyi Guo, Jinyong Wang, Shunhua Zhang, Li Zhu(1178)

Research Article

genotoxicity study of silver nanoparticles and titanium dioxide nanoparticles……………………………………………………………………Haimei Zhu, Pengcheng Huang, Tiantian Zhao, Changhui Zhou, Ruowan Li, Chunrong Yu, Zhiyong Chen, Linfeng Gu, Yan Chang(1192)

RNA-binding protein Roquin negatively regulates STING-dependent innate immune response in……………………………………………………………………Beibei Du, Lei Liu, Yangyang Zhu(1201)

Genetics Teaching

How to teach genetic drift……………………………………………………………………Chunming Wang, Changjun Lin, Huyuan Feng(1211)

（卷終）