高秦　馬東洋

[摘要]目的：觀察派力奧軟膏在智齒冠周炎治療中的療效。方法：選取2018年3月-2019年11月筆者科室診治的92例急性下頜智齒冠周炎患者為研究對象，隨機分為派力奧實驗組和碘甘油對照組，實驗組盲袋內將派力奧軟膏緩慢注入袋底，1次給藥;對照組盲袋內用探針導入2%碘甘油，1次/d，連續(xù)治療3d，兩組患者用藥5d后觀察療效及安全性。結果：治療后，對照組和治療組的總有效率分別為96%、78%，治療組療效明顯優(yōu)于對照組。結論：派力奧軟膏是治療下頜智齒冠周炎的一種安全、有效的藥物，值得臨床推廣應用。

[關鍵詞]派力奧;米諾環(huán)素;智齒冠周炎;局部用藥;療效

[中圖分類號] R781.4+2? ? [文獻標志碼]A? ? [文章編號]1008-6455（2020）08-0155-02

The Effect of Minocycline Hydrochloride Ointment on Pericoronitis

of? Wisdom Tooth

GAO? Qin1，MA Dong-yang2

（1.Department of Ophthalmology and Otorhinolaryngology，People's Liberation Army 96604 Troop Hospital，Lanzhou 730030，Gansu，China; 2. Department of Maxillofacial Surgery， PLA Joint Logistic Support Force 940 Hospital， Lanzhou 730000， Gansu，China）

Abstract： Objective To observe the effect of Minocycline Hydrochloride Ointment on pericoronitis of wisdom tooth. Methods Select our hospital from March 2018 to November 2019 were among the 92 cases of pericoronitis of? wisdom tooth as research object， 92 patients with pericoronitis were divided into 2 groups. One group was treated with Minocycline Hydrochloride Ointment and the other group was treated with iodoglycerin . Patients in the treatment group were treated with Minocycline Hydrochloride Ointment one time. Patients in the control group were treated with iodoglycerin one time daily. continuous treatment three days， 5days later. The effect of two groups was observed. Results? The clinical effect of two groups were 96% and 78%， The cilinical effect of the group treated with Minocycline Hydrochloride Ointment was much better than the group treated with iodoglycerin. Conclusion The treatment of pericoronitis of wisdom tooth with Minocycline Hydrochloride Ointment is effective， safe and worthy of promotion.

Key words：palio;minocycline hydrochloride ointment; pericoronitis;topical remedy;tjerapy

智齒冠周炎是口腔科的常見病和多發(fā)病，是發(fā)生在第三磨牙周圍軟組織的炎癥，由于下頜第三磨牙萌出最晚，萌出位置常發(fā)生不足，智齒萌出時牙齒萌出不全或異位阻生，致使部分牙冠被牙齦覆蓋，形成盲袋，容易積存食物殘渣及細菌，因其位置較深，而日常口腔清潔較難將其徹底清理干凈，最終可促使細菌不斷繁殖生長[1]，導致智齒冠周發(fā)生炎癥，臨床上以下頜智齒冠周炎多見[2]，通常發(fā)生在18～25歲的青年人群。早期一般全身無明顯反應，僅表現患側后牙區(qū)脹痛不適，進食和吞咽時疼痛加重，進一步發(fā)展局部呈自發(fā)性跳痛，當炎癥侵犯到咀嚼肌時會出現張口受限，局部炎癥繼續(xù)發(fā)展，出現全身癥狀及鄰近組織間隙感染等并發(fā)癥[3]。因此，早期有效控制感染是治療關鍵。為進一步探討局部使用派力奧治療智齒冠周炎的臨床可行性，筆者科室應用派力奧軟膏作為局部用藥，獲得了較好的臨床療效，現將結果報道如下。

1? 資料和方法

1.1 一般資料：選取筆者醫(yī)院口腔門診2018年3月-2019年11月診治的急性下頜智齒冠周炎早期患者92例，其中男70例，女22例，年齡18～25歲，多表現為患側智齒萌出不全（其中正中阻生9例、近中阻生54例、遠中阻生29例），冠周軟組織紅腫疼痛，牙齦紅腫糜爛，有深盲袋，袋內溢膿，張口受限等局部癥狀，均無明顯間隙感染及全身癥狀，均未口服抗菌素。將患者隨機分為派力奧組46例和對照組46例。