林建豐 莊澤吟 陳淑特

[摘要]目的 探討枸櫞酸咖啡因在早產(chǎn)兒呼吸機(jī)輔助通氣中的臨床效果。方法 選取2017年11月～2019年2月我院新生兒重癥監(jiān)護(hù)室收治的81例需要呼吸機(jī)輔助通氣的早產(chǎn)兒作為研究對象，采用隨機(jī)數(shù)字表法將其分為觀察組（37例）與對照組（44例）。觀察組采用枸櫞酸咖啡因治療，對照組采用氨茶堿治療。比較兩組的臨床相關(guān)指標(biāo)、撤機(jī)失敗率及并發(fā)癥發(fā)生情況。結(jié)果 觀察組的有創(chuàng)通氣時間與住院時間短于對照組，住院費(fèi)用低于對照組，出院時體重增長量多于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。兩組的無創(chuàng)輔助通氣時間比較，差異無統(tǒng)計學(xué)意義（P>0.05）。兩組的撤機(jī)失敗率比較，差異無統(tǒng)計學(xué)意義（P>0.05）。兩組的煩躁、心率增快、血糖升高、消化系統(tǒng)癥狀、支氣管肺發(fā)育不良發(fā)生率比較，差異無統(tǒng)計學(xué)意義（P>0.05）。結(jié)論 呼吸機(jī)輔助通氣的早產(chǎn)兒早期聯(lián)合使用枸櫞酸咖啡因治療，能有效縮短有創(chuàng)機(jī)械輔助通氣時間，降低撤機(jī)失敗率，縮短住院時間，減少住院費(fèi)用，但在無創(chuàng)呼吸機(jī)輔助通氣中，氨茶堿的療效與枸櫞酸咖啡因相當(dāng)，兩者的并發(fā)癥發(fā)生率差別不明顯。

[關(guān)鍵詞]咖啡因;氨茶堿;通氣機(jī);機(jī)械;嬰兒;早產(chǎn)

[中圖分類號] R969.4 ? ? ? ? ?[文獻(xiàn)標(biāo)識碼] A ? ? ? ? ?[文章編號] 1674-4721（2019）12（b）-0159-04

Clinical effect of Caffeine Citrate in ventilator assisted treatment of premature infants

LIN Jian-feng ? ZHUANG Ze-yin ? CHEN Shu-te

Department of Neonatology， Pengpai Memorial Hospital Affiliated to Guangdong Medical University in Haifeng County， Guangdong Province， Haifeng ? 516400， China

[Abstract] Objective To investigate the clinical effect of Caffeine Citrate in ventilator assisted treatment of premature infants. Methods A total of 81 premature infants requiring ventilator assisted ventilation admitted to the Neonatal Intensive Care Unit in our hospital from November 2017 to February 2019 were selected as study subjects， they were divided into the observation group （37 cases） and the control group （44 cases） by the random number table method. The observation group was treated with Caffeine Citrate， while the control group was treated with Aminophylline. The clinical relevant indicators， weaning failure rate and incidence of complication were compared between the two groups. Results The duration of invasive ventilation and the length of hospitalization in the observation group were shorter than those in the control group， the cost of hospitalization was lower than that in the control group， and the weight gain at discharge was more than that in the control group， with statistically significant differences （P<0.05）. There was no significant difference in the duration of non-invasive assisted ventilation between the two groups （P>0.05）. There was no significant difference in the weaning failure rate between the two groups （P>0.05）. There were no significant differences in irritability， increased heart rate， elevated blood sugar， digestive symptoms， and incidence of bronchopulmonary dysplasia between the two groups （P>0.05）. Conclusion For premature infants who are treated with mechanical ventilation， the use of Caffeine Citrate can effectively reduce the duration of invasive mechanical ventilation， failure rate of ventilator removal， the length and cost of hospitalization， but in the treatment of noninvasive mechanical ventilation， the treatment effect of Aminophylline is equivalent to Caffeine Ciatrate， there is no statistically significant difference in the incidence of complication between the two groups.