張潔

[摘要] 目的 觀察左甲狀腺素鈉片對(duì)妊娠伴甲狀腺功能減退（甲減）患者血脂與甲狀腺功能水平的影響。方法 便利選擇2016年11月—2018年10月該院治療的100例妊娠伴甲減患者，按隨機(jī)數(shù)字表法分為兩組，均50例。對(duì)照組接受常規(guī)治療，觀察組則加用左甲狀腺素鈉治療。觀察兩組治療前后血脂指標(biāo)[三酰甘油（TG）、總膽固醇（TC）]與甲狀腺功能指標(biāo)[促甲狀腺激素（TSH）、游離甲狀腺素（FT4）、游離三碘甲狀腺原氨酸（FT3）]。 結(jié)果 治療前兩組TG、TC、FT4、FT3、TSH水平對(duì)比，差異無(wú)統(tǒng)計(jì)學(xué)意義（t=0.319、0.186、0.374、0.605、0.238，P=0.750、0.853、0.709、0.547、0.812）;治療后觀察組FT4（18.44±2.67）pmol/L、FT3（5.76±0.80）pmol/L較對(duì)照組（10.86±1.59）pmol/L、（3.37±0.49）pmol/L高，TG（2.10±0.22）mmol/L、TC（4.23±0.57）mmol/L、TSH（2.01±0.29）mU/L較對(duì)照組（2.85±0.35）mmol/L、（5.31±0.64）mmol/L、（2.43±0.46）mU/L低，兩組對(duì)比，差異有統(tǒng)計(jì)學(xué)意義（t=17.248、18.014、12.829、8.911、5.462，P=0.000）。結(jié)論 妊娠伴甲減患者接受左甲狀腺素鈉片治療有助于調(diào)節(jié)血脂水平，改善甲狀腺功能。

[關(guān)鍵詞] 妊娠;甲狀腺功能減退;左甲狀腺素鈉;血脂;甲狀腺功能

[中圖分類號(hào)] R5? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] A? ? ? ? ? [文章編號(hào)] 1674-0742（2019）12（c）-0094-03

Effect of Levothyroxine Sodium Tablets on Blood Lipids and Thyroid Function in Pregnant Patients with Hypothyroidism

ZHANG Jie

Department of Endocrinology， People's Hospital of Liuhe District， Nanjing Gulou Hospital Group， Nanjing， Jiangsu Province， 210000 China

[Abstract] Objective To observe the effects of levothyroxine sodium tablets on blood lipids and thyroid function in patients with hypothyroidism （hypothyroidism）. Methods Convenient select 100 patients with pregnancy-related hypothyroidism who were treated in the hospital from November 2016 to October 2018 were randomly divided into two groups， 50 cases in each group. The control group received routine treatment and the observation group was treated with levothyroxine sodium. Observed the blood lipid indexes [triacylglycerol （TG）， total cholesterol （TC）] and thyroid function indicators [thyroid stimulating hormone （TSH）， free thyroxine （FT4）， free triiodothyronine （FT3）] before and after treatment. Results There were no significant differences in the levels of TG， TC， FT4， FT3 and TSH between the two groups before treatment （t=0.319， 0.186， 0.374， 0.605， 0.238， P=0.750， 0.853， 0.709， 0.547， 0.812）. The observation group FT4（18.44±2.67） pmol/L， FT3 （5.76±0.80） pmol/L was higher than the control group （10.86±1.59） pmol/L， （3.37±0.49） pmol/L， TG （2.10±0.22）mmol/L， TC （4.23±0.57） mmol/L， TSH （2.01 ± 0.29） mU / L compared with the control group （2.85±0.35）mmol/L，（5.31 ± 0.64）mmol/L， （2.43±0.46） mU/L， lower， and the difference between the two groups was statistically significant（t=17.248， 18.014， 12.829， 8.911， 5.462， P=0.000）. Conclusion Patients with pregnancy with hypothyroidism receiving levothyroxine sodium tablets can help regulate blood lipid levels and improve thyroid function.