0.05)。實(shí)驗(yàn)組的尿蛋白定量(≥3.5 g/24 h)、視網(wǎng)膜病變、高血壓等發(fā)生率均低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P[關(guān)鍵詞] 糖尿病腎病;免疫球蛋白A腎病;臨床病"/>
林福龍
[摘要] 目的 分析糖尿病腎病合并IgA腎病的臨床病理特征及治療預(yù)后。方法 選擇2017年1月—2019年1月該院收治56例糖尿病腎病合并IgA腎病患者為實(shí)驗(yàn)組。將同期收治的55例糖尿病腎病未合并IgA腎病患者為對(duì)照組。比較兩組臨床病理特征及治療預(yù)后。結(jié)果 血糖水平比較,空腹血糖、餐后2 h血糖水平比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05)。實(shí)驗(yàn)組的尿蛋白定量(≥3.5 g/24 h)、視網(wǎng)膜病變、高血壓等發(fā)生率均低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。生存率比較,實(shí)驗(yàn)組低于對(duì)照組[(96.43%(54/56) vs 98.18%(54/55)],差異無(wú)統(tǒng)計(jì)學(xué)意義(χ2=0.324,P=0.569)。結(jié)論 糖尿病腎病合并IgA腎病與糖尿病腎病未合并IgA患者,比較二者臨床病理特點(diǎn),表示其相似性與差異性并存,治療后預(yù)后效果良好。
[關(guān)鍵詞] 糖尿病腎病;免疫球蛋白A腎病;臨床病理特征;治療預(yù)后;分析
[中圖分類號(hào)] R4? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] A? ? ? ? ? [文章編號(hào)] 1672-4062(2020)10(a)-0182-03
[Abstract] Objective To analyze the clinicopathological characteristics and treatment prognosis of diabetic nephropathy combined with IgA nephropathy. Methods From January 2017 to January 2019, 56 patients with diabetic nephropathy and IgA nephropathy were admitted to the hospital as the experimental group. The 55 patients with diabetic nephropathy without IgA nephropathy who were admitted during the same period were selected as the control group. The clinicopathological characteristics and treatment prognosis of the two groups were compared. Results There was no statistically significant difference in blood glucose levels, fasting blood glucose and blood glucose levels 2 h after a meal (P>0.05). The rate of urine protein quantitative (≥3.5 g/24 h), retinopathy, and hypertension in the experimental group were lower than those in the control group, and the difference was statistically significant (P<0.05). Compared with the survival rate, the experimental group was lower than the control group[(96.43%(54/56) vs 98.18%(54/55)], which was not statistically significant difference (χ2=0.324, P=0.569). Conclusion Patients with diabetic nephropathy with IgA nephropathy and diabetic nephropathy without IgA, comparing the clinicopathological characteristics of the two indicate that their similarities and differences coexist, and the prognosis after treatment is good.
[Key words] Diabetic nephropathy; Immunoglobulin A nephropathy; Clinicopathological characteristics; Treatment prognosis; Analysis
糖尿病是一種代謝性疾病,受遺傳、免疫功能紊亂和微生物感染等因素影響,臨床表現(xiàn)為高血糖、多飲、多食、多尿以及體重消瘦等癥狀,若長(zhǎng)期處于高血糖和代謝紊亂癥狀,易損害重要器官[1]。IgA腎?。↖g Anephropathy),屬慢性腎小球腎炎,是一種進(jìn)展性疾病,發(fā)病率較高,是免疫介導(dǎo)的原發(fā)性腎小球疾病,臨床表現(xiàn)以血尿?yàn)橹?,存在蛋白尿和腎功能損傷現(xiàn)象,是終末期腎病的常見(jiàn)原因[2]。目前,臨床對(duì)糖尿病腎病合并IgA的報(bào)道比較少。為提高糖尿病合并腎臟損傷的認(rèn)識(shí),該院以2017年1月—2019年1月收治的56例糖尿病腎病合并IgA腎病患者和55例糖尿病腎病未合并IgA糖尿病腎病患者為研究對(duì)象,分析其臨床特征及治療預(yù)后,現(xiàn)報(bào)道如下。
1? 資料與方法
1.1? 一般資料
該院收治56例糖尿病腎病合并IgA腎病患者為實(shí)驗(yàn)組。將同期收治的55例糖尿病腎病未合并IgA腎病患者為對(duì)照組。其中實(shí)驗(yàn)組,男性患者29例,女性患者27例;最小年齡30歲,最大年齡78歲,平均年齡(41.29±2.28)歲;最短病程1年,最長(zhǎng)病程3年,平均病程(1.39±0.34)年。對(duì)照組,男性患者29例,女性患者26例;最小年齡30歲,最大年齡77歲,平均年齡(41.48±2.19)歲;最短病程1年,最長(zhǎng)病程3年,平均病程(1.42±0.39)年。