2023年 第45卷 總目次

第1期

編委推薦................(1)

熱點(diǎn)追蹤

兩個(gè)拮抗的bHLH轉(zhuǎn)錄因子對(duì)水稻種子休眠的調(diào)控.......................... 金晶，儲(chǔ)成才(3)

特邀綜述

遺傳修飾豬模型在生物醫(yī)學(xué)及農(nóng)業(yè)領(lǐng)域研究進(jìn)展及應(yīng)用...................................... 高菲，王煜，杜嘉祥，杜旭光，趙建國(guó)，潘登科，吳森，趙要風(fēng)(6)

綜 述

遺傳性耳聾分子診斷及梯級(jí)檢測(cè)策略應(yīng)用............... 曾焙枰，許紅恩，毛璐，湯文學(xué)(29)

誘導(dǎo)多能干細(xì)胞在兒童疾病的應(yīng)用研究進(jìn)展.................................... 田智琛，尹曉娟(42)

研究報(bào)告

轉(zhuǎn)錄組分析在血液樣本時(shí)間和供體特征刻畫(huà)中的應(yīng)用研究............................ 張瑾，劉開(kāi)會(huì)，張穎，郝金萍，張廣峰，徐小玉，暢晶晶，劉興朋，楊雪瑩，葉健(52)

過(guò)表達(dá)組蛋白H3K9me3去甲基化酶對(duì)豬克隆胚胎發(fā)育的影響............................ 李亞楠，張賢君，張寧，梁雅琳，張宇星，招華興，李紫聰，黃思秀(67)

實(shí)驗(yàn)操作指南

利用CRISPR/Cas9技術(shù)構(gòu)建基因編輯大鼠模型......................... 劉梅珍，王立人，李詠梅，馬雪云，韓紅輝，李大力(78)

遺傳資源

一例X染色體結(jié)構(gòu)重排導(dǎo)致DMD疾病....................胡浩，楊曉文，程德華，李秀蓉，何文斌，胡曉，高伯笛，趙曉蒙，張前軍，杜娟，劉激揚(yáng)，盧光琇，林戈，李汶(88)

撤稿聲明

撤稿：誘導(dǎo)多能干細(xì)胞技術(shù)及其在疾病研究中的應(yīng)用[遺傳,2020,42(11):1042–1061]...................(95)

綜合信息

致謝2022年度審稿編委和審稿專家...................(96)

第2期

編委推薦...................(97)

綜 述

核受體REV-ERBα整合生物鐘與能量代謝......................... 冒姝羽，趙昌睿，劉暢(99)

FSCN1在乳腺癌發(fā)生發(fā)展中的作用及其調(diào)控機(jī)制....................................... 常棟，劉享享，劉睿，孫建偉(115)

基因滲入的檢測(cè)和表征方法........................... 劉澤璇，趙毅強(qiáng)(128)

研究報(bào)告

脂肪細(xì)胞促進(jìn)高脂飲食誘導(dǎo)肥胖.......................... 王瀾，曾帆，黃榮鳳，林樹(shù)，張志輝，李旻典(144)

甘藍(lán)DELLA基因家族鑒定及其mRNA在嫁接體中的運(yùn)輸分析.................................. 李必元，趙彥婷，岳智臣，雷娟利，胡齊贊，陶鵬(156)

實(shí)驗(yàn)操作指南

CRISPR-Cas9基因編輯技術(shù)對(duì)細(xì)胞內(nèi)源蛋白進(jìn)行熒光標(biāo)記的實(shí)驗(yàn)操作..................................... 吳仲勝，高譽(yù)，杜勇濤，黨頌，何康敏(165)

遺傳學(xué)教學(xué)

以A2型短指(趾)癥為案例的醫(yī)學(xué)遺傳學(xué)PBL教學(xué)設(shè)計(jì)............. 馬捷，黃露杰，張巧霞，朱艷，錢(qián)露(176)

第3期

編委推薦................(185)

優(yōu)博專欄

跨組織線粒體應(yīng)激信號(hào)交流調(diào)控機(jī)體衰老研究進(jìn)展................... 張茜，王子豪，田燁(187)

綜 述

單細(xì)胞轉(zhuǎn)錄組測(cè)序在少突膠質(zhì)譜系細(xì)胞異質(zhì)性與神經(jīng)系統(tǒng)疾病中的應(yīng)用.............................. 韓熙，羅富成(198)

組織蛋白酶B參與腦衰老及阿爾茲海默癥發(fā)生發(fā)展研究進(jìn)展......................... 商曉康，張思萌，倪軍軍(212)

果蠅限制端粒轉(zhuǎn)座子的分子機(jī)制............................. 王承賢，容益康，崔敏(221)

JAK/STAT信號(hào)通路及其對(duì)昆蟲(chóng)免疫的調(diào)控......................... 韋湘怡，胡冬春，高祖鵬，馮從經(jīng)(229)

研究報(bào)告

基于WGCNA發(fā)掘缺磷、紅光和黃光處理下三角褐指藻巖藻黃素合成關(guān)鍵基因.......................... 呂嬌，龔一富，章麗，胡媛，王何瑜(237)

技術(shù)與方法

用于循環(huán)腫瘤細(xì)胞定量分析的數(shù)字PCR檢測(cè)方法的建立及性能驗(yàn)證.................................... 馬春輝，胡海旭，張麗娟，劉毅，劉天懿(250)

遺傳資源

一例以多發(fā)性骨破壞為顯著特征的老年戈謝病的診療和基因檢測(cè)分析......................... 秦姝超，尹華，王蓉，朱飛鵬，李建勇，盧瑞南(261)

第4期

編委推薦....................(271)

前沿聚焦

哺乳動(dòng)物卵子與早期胚胎中全轉(zhuǎn)錄組poly(A)尾研究進(jìn)展................. 王文龍，張春霞(273)

綜 述

Hi-C 技術(shù)在三維基因組學(xué)和疾病致病機(jī)理研究中的應(yīng)用.......... 王舜澤，江豐，朱東麗，楊鐵林，郭燕(279)

綿羊突變對(duì)BMPR1B活性及BMP/SMAD通路的影響研究進(jìn)展...................................... 龔一鳴，王翔宇，賀小云，劉玉芳，余平，儲(chǔ)明星，狄冉(295)

可視化分析在病原體核酸現(xiàn)場(chǎng)快速檢測(cè)中的研究進(jìn)展........................... 劉丹妮，武海萍，周國(guó)華(306)

研究報(bào)告

利用人類全基因組亞硫酸氫鹽測(cè)序數(shù)據(jù)檢測(cè)CNVs的研究............................ 徐丹同，王祎菲，蔡佳麗，龔文滔，潘向春，田雨晗，沈箐鵬，李加琪，袁曉龍(324)

尿囊素促進(jìn)破骨細(xì)胞缺陷斑馬魚(yú)骨折修復(fù).............................. 李凱倫，盧荊奧，陳小輝，張文清，劉偉(341)

遺傳學(xué)教學(xué)

現(xiàn)代計(jì)算機(jī)技術(shù)在遺傳學(xué)實(shí)驗(yàn)教學(xué)中的應(yīng)用——移動(dòng)端輕量級(jí)高精度果蠅遺傳性狀批量識(shí)別系統(tǒng)的開(kāi)發(fā) .......................安鈞浩，趙雪瑩，喬守怡，盧大儒，皮妍(354)

第5期

編委推薦....................(365)

優(yōu)博專欄

水稻分蘗氮響應(yīng)調(diào)控機(jī)理研究進(jìn)展................. 劉永強(qiáng)，李威威，劉昕禹，儲(chǔ)成才(367)

綜 述

哺乳動(dòng)物卵母細(xì)胞的DNA損傷與修復(fù)研究進(jìn)展....................... 張楠，張玨，林戈(379)

STIM1在腫瘤發(fā)生及轉(zhuǎn)移中的研究進(jìn)展........... 嚴(yán)程浩，白韋鈺，張智猛，沈俊嶺，王友軍，孫建偉(395)

生物鐘作用機(jī)制及其對(duì)動(dòng)物年節(jié)律產(chǎn)生的影響................. 楊陽(yáng)，儲(chǔ)明星，劉秋月(409)

研究報(bào)告

生酮飲食激活脂肪酸氧化促進(jìn)ME區(qū)的少突膠質(zhì)細(xì)胞前體細(xì)胞增殖.......................... 王奔，李斯，吳青峰，穆文輝(425)

miR-196b-5p促進(jìn)成肌細(xì)胞增殖分化....................... 吳玲玲，張小玉，李曉，靳建軍，楊公社，史新娥(435)

雞基因組及轉(zhuǎn)錄本結(jié)構(gòu)分析................................. 高智慧，黃佳新，羅昊玉，徐海冬，婁明，寧博林，邢曉旭，牟芳，李輝，王寧(447)

勘 誤

勘誤：CRISPR/Cas9系統(tǒng)在林木基因編輯中的應(yīng)用.............................. 陳贏男，陸靜(446)

第6期

編委推薦....................(459)

熱點(diǎn)追蹤

雜交物種形成促進(jìn)哺乳動(dòng)物多樣性演化—以金絲猴屬()為例.......... 章譽(yù)興，吳宏，于黎(461)

前沿聚焦

外顯子拼接復(fù)合體塑造m6A表觀轉(zhuǎn)錄組的形成............... 宋鵬輝，馬麗娟，嚴(yán)冬(464)

綜 述

6-甲基腺苷修飾對(duì)女性生殖系統(tǒng)功能的影響......................... 何山，趙健，宋曉峰(472)

兩側(cè)對(duì)稱動(dòng)物左右不對(duì)稱發(fā)生機(jī)制研究進(jìn)展............... 邢超凡，王閩濤，王磊，申欣(488)

植物質(zhì)體基因工程調(diào)控元件研究進(jìn)展....................................... 于一凡，歐陽(yáng)臻，郭娟，趙瑜君，黃璐琦(501)

研究報(bào)告

基因新突變導(dǎo)致卵母細(xì)胞成熟阻滯為特征的女性不孕................................. 呂香江，郭靜，林戈(514)

金魚(yú)草基因克隆與功能研究................................. 李菲菲，郝燕敏，崔敏龍，樸春蘭(526)

遺傳資源

一例基因復(fù)合雜合變異所致的肢帶型肌營(yíng)養(yǎng)不良癥2U型的診斷和基因檢測(cè)分析............................ 黃娟，繆文華，郭曉峰，吉煒(536)

第7期

編委推薦....................(543)

領(lǐng)域動(dòng)態(tài)

國(guó)外畜禽遺傳資源保護(hù)及對(duì)我國(guó)的啟示................................... 陳曉，陸健，于福清(545)

綜 述

發(fā)育性和癲癇性腦病遺傳學(xué)病因及診療的研究進(jìn)展............... 金良，陳語(yǔ)婕，陳勇軍(553)

伴皮質(zhì)下梗死和白質(zhì)腦病的常染色體顯性遺傳性腦動(dòng)脈病的發(fā)病機(jī)制及治療研究進(jìn)展.............................. 張翌，吳志英(568)

研究報(bào)告

E2F家族轉(zhuǎn)錄因子在腫瘤發(fā)生中的作用................. 李飛飛，王韻，顧冀海，張玉明，柳峰松，倪志華(580)

利用單轉(zhuǎn)錄本表達(dá)Cas9和sgRNA條件性編輯果蠅基因組..................... 王秉政，張超，張佳麗，孫錦(593)

全基因組重測(cè)序解析秦川牛保種群遺傳多樣性和遺傳結(jié)構(gòu)........................................ 馬鈞，樊安平，王武生，張金川，江曉軍，馬瑞軍，賈社強(qiáng)，劉飛，雷初朝，黃永震(602)

遺傳資源

一例嬰兒神經(jīng)軸索營(yíng)養(yǎng)不良的診療與基因檢測(cè)分析..................... 宮為大，陶鋼，趙甜甜，楊悅，紀(jì)紅(617)

會(huì)議簡(jiǎn)訊

第一屆全國(guó)遺傳領(lǐng)域標(biāo)準(zhǔn)化論壇暨中國(guó)遺傳學(xué)會(huì)標(biāo)準(zhǔn)化技術(shù)委員會(huì)成立大會(huì)在上海成功召開(kāi)............ 郭云峰，許俊(624)

第8期

編委推薦....................(627)

熱點(diǎn)追蹤

菌源同工酶分析揭示菌源DPP4同工酶是潛在的抗2型糖尿病靶點(diǎn)................. 張志威，汪鍇，姜長(zhǎng)濤(629)

綜 述

線粒體DNA堿基編輯技術(shù)研究進(jìn)展....................... 宋睿嘉，韓露，孫海峰，沈彬(632)

痛風(fēng)的多組學(xué)研究進(jìn)展................. 時(shí)文睿，渠鴻竹，方向東(643)

研究報(bào)告

AFF4在人類HEL細(xì)胞中廣泛地影響RNA聚合酶II的停滯釋放............................... 楊子玫，張格，魏剛，經(jīng)莉莉，于明(658)

數(shù)據(jù)驅(qū)動(dòng)的人體正常和癌癥組織中糖基磷脂酰肌醇錨定蛋白(GPI-AP)相關(guān)基因表達(dá)譜的綜合分析........................... 孔維澤，柳藝石，高曉冬，藤田盛久(669)

巨噬細(xì)胞相關(guān)基因與非小細(xì)胞肺癌預(yù)后和腫瘤微環(huán)境的分析....................................... 孫清玙，周陽(yáng)，杜麗娟，張夢(mèng)珂，王家樂(lè)，任媛媛，劉芳(684)

鐵皮石斛WOX家族基因在生長(zhǎng)發(fā)育中的功能分析......................... 陳凱，王灝，陳燚婷，符可，韓之剛，李聰，斯金平，陳東紅(700)

第9期

前 言

作物分子設(shè)計(jì)育種與從頭馴化...................... 譚祿賓，孫傳清(715)

綜 述

水稻分子設(shè)計(jì)育種啟示：傳統(tǒng)與現(xiàn)代相結(jié)合............ 卞中，曹東平，莊文姝，張舒瑋，劉巧泉，張林(718)

從頭馴化：作物品種設(shè)計(jì)與培育的新方向..................... 簡(jiǎn)六梅，肖英杰，嚴(yán)建兵(741)

植物開(kāi)花調(diào)控中蛋白質(zhì)相分離機(jī)制在從頭馴化中的應(yīng)用價(jià)值............................ 田璐妍，黃小珍(754)

長(zhǎng)雄野生稻有利基因的發(fā)掘與利用.......................... 廉小平，黃光福，張玉嬌，張靜，胡鳳益，張石來(lái)(765)

同源四倍體水稻：低育性機(jī)理、改良與育種展望...................................... 劉向東，吳錦文，陸紫君，Muhammad Qasim Shahid(781)

大豆光周期適應(yīng)性研究進(jìn)展.................... 賴筆威，陳磊，蘆思佳(793)

氮素調(diào)控花生共生結(jié)瘤的機(jī)制研究進(jìn)展...... 曾瑞兒，耿慶輝，高恒寬，潘晴晴，陳婷婷，陳勇，張雷(801)

植物小肽信號(hào)生物學(xué)功能及其在作物改良中研究進(jìn)展..................... 呂倩雯，楊永芳(813)

遺傳資源

中科發(fā)早粳1號(hào)分子設(shè)計(jì)育種................... 陳明江，劉貴富，肖葉青，余泓，李家洋(829)

研究報(bào)告

水稻調(diào)控籽粒大小與株型.................................... 鄭鎮(zhèn)武，趙宏源，梁曉婭，王一珺，王馳航，鞏高洋，黃金燕，張桂權(quán)，王少奎，劉祖培(835)

通過(guò)合成不同活性GA調(diào)控水稻育性及株高....................................... 郝小花，胡爽，趙丹，田連福，謝子靖，吳莎，胡文俐，雷晗，李東屏(845)

第10期

編委推薦....................(857)

綜 述

大規(guī)模平行報(bào)告基因測(cè)定：一種分析基因表達(dá)調(diào)控的新技術(shù)................................... 袁萌，李輝，王守志(859)

溶酶體酶PPT1介導(dǎo)的細(xì)胞穩(wěn)態(tài)調(diào)控及疾病發(fā)生的研究進(jìn)展......................... 周欣怡，常棟，徐黃瑩，關(guān)瑞琪，嚴(yán)程浩，尹秋媛，孫建偉(874)

噬菌體Z基因組生物合成通路的研究進(jìn)展........................................ 陳薈玉，趙素文(887)

研究報(bào)告

基于比較基因組學(xué)的解脂亞羅酵母CA20高產(chǎn)赤蘚糖醇機(jī)理及進(jìn)化分析........................................ 夏凱，劉芳美，陳雨晴，陳珊珊，黃春瑩，趙學(xué)群，沙如意，黃俊(904)

基于機(jī)器學(xué)習(xí)的豬生長(zhǎng)性狀基因組預(yù)測(cè)............................ 陳棟，王書(shū)杰，趙真堅(jiān)，姬祥，申琦，余楊，崔晟頔，王俊戈，陳子旸，王金勇，郭宗義，吳平先，唐國(guó)慶(922)

技術(shù)與方法

基于全局最小殘差法快速分析混合STR圖譜............................. 李鑫，范虹，趙興春，范曉諾，姚若俠(933)

第11期

前 言

解析病原體與宿主相互作用機(jī)制 應(yīng)對(duì)全球新發(fā)突發(fā)傳染病挑戰(zhàn)................ 謝建平，肖永紅，周鋼橋(945)

綜 述

CRISPR基因組編輯技術(shù)在傳染病致病機(jī)理研究和防診治中的應(yīng)用................................ 楊臻嶸，周鋼橋(950)

新冠肺炎遺傳易感基因的研究進(jìn)展...................... 李元豐，吳天準(zhǔn)，陳順琦，王玉婷，曾濤，李若凡，周鋼橋(963)

甲型流感病毒宿主適應(yīng)的分子基礎(chǔ)及其相關(guān)宿主因子的研究進(jìn)展.......................... 孫婷婷，岑山，王靜(976)

病原體逃逸宿主固有免疫的新策略：抑制細(xì)胞焦亡........................................ 楊茂藝，崔瀟月，鄭詩(shī)棋，馬詩(shī)瑤，鄭增長(zhǎng)，鄧萬(wàn)燕(986)

USP18介導(dǎo)的蛋白質(zhì)去ISG化及其在結(jié)核病等傳染病中的作用.................................. 張其奧，王子路，李佩波，謝建平(998)

鳥(niǎo)苷酸結(jié)合蛋白家族在感染性疾病中調(diào)控炎癥小體活化的研究進(jìn)展.................. 全舒婷，焦偉偉，徐放，孫琳，綦輝，申阿東(1007)

分枝桿菌非典型錯(cuò)配修復(fù)及其在抗生素耐藥中的研究進(jìn)展............... 向莎莎，謝建平(1018)

艱難梭菌抗菌藥物耐藥機(jī)制研究進(jìn)展.................... 胥騰，黃海輝(1028)

研究報(bào)告

hsa_circ_0007460通過(guò)調(diào)節(jié)巨噬細(xì)胞的自噬和凋亡影響細(xì)胞內(nèi)結(jié)核分枝桿菌的存活.................................... 章金怡，何禹墨，周晶雨，翁術(shù)鋒，馬慧霞，林太玥，徐穎(1039)

糖尿病與非糖尿病患者社區(qū)獲得性高毒肺炎克雷伯菌肝膿腫臨床及病原學(xué)特征比較.................................. 葉靜，王媛，熊璐穎，肖永紅(1052)

兩起發(fā)熱伴血小板減少綜合征聚集性疫情流行病學(xué)及病原學(xué)分析.............................. 楊鑫，武永祥，冷昱，李佳宸，王超杰，袁義美，王震，張?zhí)m，黎浩，劉瑋(1062)

杭州地區(qū)2012～2018年耐甲氧西林金黃色葡萄球菌的分子流行病學(xué)特征及其變化趨勢(shì)............................. 朱云穎，王媛，肖婷婷，嵇金如，沈萍，肖永紅(1074)

第12期

編委推薦....................(1085)

特邀綜述

人類卵母細(xì)胞減數(shù)分裂的生理和病理機(jī)制................................... 周舟，桑慶，王磊(1087)

綜 述

分枝桿菌T7SS(ESX)分泌系統(tǒng)功能研究進(jìn)展................................... 蔣智勇，謝建平(1100)

基因芯片在畜禽遺傳育種中的應(yīng)用及展望.............. 汪佳豪，趙卿堯，周月玲，史良玉，王楚端，俞英(1114)

研究報(bào)告

絲狀真菌AA11家族裂解多糖單加氧酶基因的鑒定和功能研究..................................... 杜文珍，李元敬，吳佳玲，陳思羽，姜亮，劉剛，謝寧(1128)

寧鄉(xiāng)豬皮下脂肪與肌內(nèi)脂肪組織轉(zhuǎn)錄組差異分析........................... 王芳，張躍博，蔣謙，印遇龍，譚碧娥，陳家順(1147)

遺傳學(xué)教學(xué)

基于科教融合培養(yǎng)大學(xué)生拔尖創(chuàng)新能力的表觀遺傳學(xué)綜合實(shí)驗(yàn)課程.......................... 歐秀芳，吳瑩，李寧，姜麗麗，劉寶，宮磊(1158)

No. 1

Invited Review

Advances and applications of genetically modified pig models in biomedical and agricultural field.......................... Fei Gao,Yu Wang,Jiaxiang Du,Xuguang Du,Jianguo Zhao,Dengke Pan,Sen Wu,Yaofeng Zhao(6)

Review

Molecular diagnosis of hereditary deafness and application of stepwise testing strategy.............................. Beiping Zeng,Hongen Xu,Lu Mao,Wenxue Tang(29)

Advances in the application of induced pluripotent stem cells in pediatric diseases....................... Zhichen Tian,Xiaojuan Yin(42)

Research Article

Application of transcriptome in time analysis and donor characterization in blood samples........................................ Jin Zhang,Kaihui Liu,Ying Zhang,Jinping Hao,Guangfeng Zhang,Xiaoyu Xu,Jingjing Chang,Xingpeng Liu,Xueying Yang,Jian Ye(52)

Effects of overexpression of histone H3K9me3 demethylase on development of porcine cloned embryos................................ Yanan Li,Xianjun Zhang,Ning Zhang,Yalin Liang,Yuxing Zhang, Huaxing Zhao,Zicong Li,Sixiu Huang(67)

Protocol

Generation of genetically modified rat models via the CRISPR/Cas9 technology........................................ Meizhen Liu,Liren Wang,Yongmei Li,Xueyun Ma,Honghui Han,Dali Li(78)

Genetic Resource

A DMD case caused by X chromosome rearrangement ................................. Hao Hu,Xiaowen Yang,Dehua Cheng,Xiurong Li,Wenbin He,Xiao Hu,Bodi Gao, Xiaomeng Zhao,Qianjun Zhang,Juan Du,Jiyang Liu,Guangxiu Lu,Lin Ge,Wen Li(88)

No. 2

Review

The nuclear receptor REV-ERBα integrates circadian clock and energy metabolism..................................................... Shuyu Mao,Changrui Zhao,Chang Liu(99)

The role and regulatory mechanism of FSCN1 in breast tumorigenesis and progression............................................................... Dong Chang,Xiangxiang Liu,Rui Liu,Jianwei Sun(115)

Methods to detect and characterize introgression................... Zexuan Liu,Yiqiang Zhao(128)

Research Article

Adipocyte reconstitution ofgene insilenced mice promotes diet-induced obesity..................................................... Lan Wang,Fan Zeng,Rongfeng Huang,Shu Lin,Zhihui Zhang,Min-Dian Li(144)

Identification of DELLA gene family in head cabbage and analysis of mRNA transport in the heterograft.............................. Biyuan Li,Yanting Zhao,Zhichen Yue,Juanli Lei,Qizan Hu,Peng Tao(156)

Protocol

The protocol of tagging endogenous proteins with fluorescent tags using CRISPR-Cas9 genome editing.................................... Zhongsheng Wu,Yu Gao,Yongtao Du,Song Dang,Kangmin He(165)

Genetics Teaching

PBL teaching design of medical genetics with the case of brachydactyly type A2............................................ Jie Ma,Lujie Huang,Qiaoxia Zhang,Yan Zhu,Lu Qian(176)

No. 3

Special Section: Excellent Doctoral Thesis

Inter-tissue communication of mitochondrial stress in aging......................... Qian Zhang,Zihao Wang,Ye Tian(187)

Review

Application of single-cell RNA sequencing in probing oligodendroglia heterogeneity and neurological disorders............................. Xi Han,Fucheng Luo(198)

Research progress of cathepsin B in brain aging and Alzheimer’s diseases............................................. Xiaokang Shang,Simeng Zhang,Junjun Ni(212)

The molecular mechanism ofrestricting telomeric transposons............................................ Chengxian Wang,Yikang S. Rong,Min Cui(221)

JAK/STAT signaling pathway and its regulation on insect immunity........................................................ Xiangyi Wei,Dongchun Hu,Zupeng Gao,Congjing Feng(229)

Research Article

Exploring the key genes of fucoxanthin biosynthesis inunder phosphorus deficiency, red light and yellow light using WGCNA..........................................Jiao Lv,Yifu Gong,Li Zhang,Yuan Hu,Heyu Wang(237)

Technique and Method

Establishment and verification of a digital PCR assay for the detection ofexpression in quantitative analysis of circulating tumor cell.......................... Chunhui Ma,Haixu Hu,Lijuan Zhang,Yi Liu,Tianyi Liu(250)

Genetic Resource

Diagnosis,treatment and genetic analysis of an elderly patient with Gaucher’s disease characterized by marked multiple bone destruction.................... Shuchao Qin,Hua Yin,Rong Wang,Feipeng Zhu,Jianyong Li,Ruinan Lu(261)

No. 4

Frontier Focus

Research progress on the study of transcriptome-wide poly(A) tails in mammalian oocytes and early embryos....................... Wenlong Wang,Chunxia Zhang(273)

Review

Application of Hi-C technology in three-dimensional genomics research and disease pathogenesis analysis............................... Shunze Wang,Feng Jiang,Dongli Zhu,Tie-Lin Yang,Yan Guo(279)

Progress on the effect ofmutation on BMPR1B activity and BMP/SMAD pathway in sheep........................................... Yiming Gong,Xiangyu Wang,Xiaoyun He,Yufang Liu,Ping Yu,Mingxing Chu,Ran Di(295)

Research progress of visual detection in rapid on-site detection of pathogen nucleic acid............................................................ Danni Liu,Haiping Wu,Guohua Zhou(306)

Research Article

Study on detection of CNVs using human whole genome bisulfite sequencing data...................................................... Dantong Xu,Yifei Wang,Jiali Cai,Wentao Gong,Xiangchun Pan,Yuhan Tian,Qingpeng Shen,Jiaqi Li,Xiaolong Yuan(324)

The role of the allantoin in promoting fracture healing in osteoclast-deficient zebrafish.............................................................. Kailun Li,Jingao Lu,Xiaohui Chen,Wenqing Zhang,Wei Liu(341)

Genetics Teaching

Application of modern computer technology in classical genetics lab course——Development of a mobile, lightweight and high-precision batch identification system for genetic traits of........................................ Junhao An,Xueying Zhao,Shouyi Qiao,Daru Lu,Yan Pi(354)

No. 5

Special Section: Excellent Doctoral Thesis

Molecular mechanism of tillering response to nitrogen in rice........................................................ Yongqiang Liu,Weiwei Li,Xinyu Liu,Chengcai Chu(367)

Review

Advances in the study of DNA damage and repair in mammalian oocytes................................................... Nan Zhang,Jue Zhang,Ge Lin(379)

The roles and mechanism of STIM1 in tumorigenesis and metastasis........................................................... Chenghao Yan,Weiyu Bai,Zhimeng Zhang,Junling Shen,Youjun Wang,Jianwei Sun(395)

The mechanism of circadian clock and its influence on animal circannual rhythm........................................... Yang Yang,Mingxing Chu,Qiuyue Liu(409)

Research Article

Ketogenic diet promotes the proliferation of oligodendrocyte precursor cells in ME region by activating fatty acid oxidation.......................... Ben Wang,Si Li,Qing-Feng Wu,Wenhui Mu(425)

miR-196b-5p promotes myoblast proliferation and differentiation............................................................ Lingling Wu,Xiaoyu Zhang,Xiao Li,Jianjun Jin,Gongshe Yang,Xin’e Shi(435)

Characterization of the genomic and transcriptional structure of chickengene ..................................Zhihui Gao,Jiaxin Huang,Haoyu Luo,Haidong Xu,Ming Lou, Bolin Ning,Xiaoxu Xing,Fang Mu,Hui Li,Ning Wang(447)

No. 6

Frontier Focus

Exon junction complex modulates the formation of the m6A epitranscriptome........................................... Penghui Song,Lijuan Ma,Dong Yan (464)

Review

Effects of6-methyladenosine modification on the function of the female reproductive system.................................................... Shan He,Jian Zhao,Xiaofeng Song (472)

Progress on the mechanism of left-right asymmetrical patterning in bilaterians................................................ Chaofan Xing,Mintao Wang,Lei Wang,Xin Shen(488)

Progress on regulatory elements of plant plastid genetic engineering........................................................... Yifan Yu,Zhen OuYang,Juan Guo,Yujun Zhao,Luqi Huang(501)

Research Article

Novel mutations inlead to female infertility with oocyte maturation arrest.......................................................... Xiangjiang Lv,Jing Guo,Ge Lin(514)

Cloning and functional analysis ofgene from...................................................... Feifei Li,Yanmin Hao,Minlong Cui,Chunlan Piao(526)

Genetic Resource

Diagnosis and genetic testing analysis of limb-girdle muscular dystrophy type 2U caused by a compound heterozygous mutation in thegene........................... Juan Huang,Wenhua Miao,Xiaofeng Guo,Wei Ji(536)

No. 7

Research Trends

Conservation of animal genetic resources in the world and its enlightenment to China..................................................... Xiao Chen,Jian Lu,Fuqing Yu(545)

Review

Advances in genetic etiology,diagnosis and treatment of developmental and epileptic encephalopathy....................................... Liang Jin,Yujie Chen,Yongjun Chen(553)

Pathogenesis and therapeutic advances of cerebral autosomal- dominant arteriopathy with subcortical infarcts and leukoencephalopathy.................... Yi Zhang,Zhi-Ying Wu(568)

Research Article

E2F family play important roles in tumorigenesis.................................................... Feifei Li,Yun Wang,Jihai Gu,Yuming Zhang,Fengsong Liu,Zhihua Ni(580)

Conditional editing of thegenome using single transcripts expressing Cas9 and sgRNA................... Bingzheng Wang,Chao Zhang,Jiali Zhang,Jin Sun(593)

Analysis of genetic diversity and genetic structure of Qinchuan cattle conservation population using whole-genome resequencing ..................................... Jun Ma,Anping Fan,Wusheng Wang,Jinchuan Zhang, Xiaojun Jiang,Ruijun Ma,Sheqiang Jia,Fei Liu,Chuchao Lei,Yongzhen Huang(602)

Genetic Resource

Diagnosis,treatment and genetic analysis of a child with infantile neuroaxonal dystrophy.............................................................. Weida Gong,Gang Tao,Tiantian Zhao,Yue Yang,Hong Ji (617)

No. 8

Review

Advances in mitochondrial DNA base editing technology.......... Ruijia Song,Lu Han,Haifeng Sun,Bin Shen(632)

Overview of multi-omics research in gout.......................... Wenrui Shi,Hongzhu Qu,Xiangdong Fang(643)

Research Article

AFF4 globally affects the release of paused RNA polymerase II in HEL cells............................................ Zimei Yang,Ge Zhang,Gang Wei,Lili Jing,Ming Yu(658)

Comprehensive in silico analysis of glycosylphosphatidylinositol- anchored protein(GPI-AP) related genes expression profiles in human normal and cancer tissues Weize Kong,Yishi Liu,Xiaodong Gao,Morihisa Fujita...............................(669)

Analysis between macrophage-related genes with prognosis and tumor microenvironment in non-small cell lung cancer............... Qingyu Sun,Yang Zhou,Lijuan Du,Mengke Zhang,Jiale Wang,Yuanyuan Ren,Fang Liu(684)

Functional analysis of WOX family genes induring growth and development........................................ Kai Chen,Hao Wang,Yiting Chen,Ke Fu,Zhigang Han,Cong Li,Jinping Si,Donghong Chen(700)

No. 9

Review

Revelation of rice molecular design breeding: the blend of tradition and modernity.......................................................... Zhong Bian,Dongping Cao,Wenshu Zhuang,Shuwei Zhang,Qiaoquan Liu,Lin Zhang(718)

domestication: a new way for crop design and breeding.......................... Liumei Jian,Yingjie Xiao,Jianbing Yan(741)

Application value of protein phase separation mechanism of flowering regulation indomestication.............................. Luyan Tian,Xiaozhen Huang(754)

The discovery and utilization of favorable genes in.................................................. Xiaoping Lian,Guangfu Huang,Yujiao Zhang,Jing Zhang,Fengyi Hu,Shilai Zhang(765)

Autotetraploid rice: challenges and opportunities..................................................... Xiangdong Liu,Jinwen Wu,Zijun Lu,Muhammad Qasim Shahid(781)

The current status of photoperiod adaptability in soybean...................................... Biwei Lai,Lei Chen,Sijia Lu(793)

Mechanism of symbiotic nodulation between nitrogen and peanut................................................................ Ruier Zeng,Qinghui Geng,Hengkuan Gao,Qingqing Pan,Tingting Chen,Yong Chen,Lei Zhang(801)

The biological functions of peptide signaling in plant and the advances on its utilization for crop improvement............................ Qianwen Lv,Yongfang Yang(813)

Genetic Resource

Breeding of ZhongKeFaZaoGeng1 by molecular design................................................ Mingjiang Chen,Guifu Liu,Yeqing Xiao,Hong Yu,Jiayang Li(829)

Research Article

controls kernel size and plant architecture in rice.......................................... Zhenwu Zheng,Hongyuan Zhao,Xiaoya Liang,Yijun Wang,Chihang Wang,Gaoyan Gong,Jinyan Huang,Guiquan Zhang,Shaokui Wang,Zupei Liu(835)

genes regulate rice fertility and plant height by synthesizing diverse active GA.............................................................. Xiaohua Hao,Shuang Hu,Dan Zhao,Lianfu Tian,Zijing Xie,Sha Wu,Wenli Hu,Han Lei,Dongping Li(845)

No. 10

Review

Massively parallel reporter assay: a novel technique for analyzing the regulation of gene expression........................................... Meng Yuan,Hui Li,Shouzhi Wang(859)

Progress on lysosomal PPT1-mediated regulation of cellular homeostasis and pathogenesis........................................................... Xinyi Zhou,Dong Chang,Huangying Xu,Ruiqi Guan,Chenghao Yan,Qiuyuan Yin,Jianwei Sun(874)

Progress on Z genome biosynthetic pathway of bacteriophage..................................... Huiyu Chen,Suwen Zhao(887)

Research Article

Mechanism and evolutionary analysis ofCA20 capable of producing erythritol with a high yield based on comparative genomics........................... Kai Xia,Fangmei Liu,Yuqing Chen, Shanshan Chen,Chunying Huang,Xuequn Zhao,Ruyi Sha,Jun Huang(904)

Genomic prediction of pig growth traits based on machine learning............................................................. Dong Chen,Shujie Wang,Zhenjian Zhao,Xiang Ji,Qi Shen,Yang Yu,Shengdi Cui,Junge Wang,Ziyang Chen,Jinyong Wang,Zongyi Guo,Pingxian Wu,Guoqing Tang(922)

Technique and Method

Rapid analyzing mixed STR profiles based on the global minimum residual method........................................................ Xin Li,Hong Fan,Xingchun Zhao,Xiaonuo Fan,Ruoxia Yao(933)

No. 11

Review

The application of CRISPR genome editing technologies in the pathogenesis studies,diagnosis,prevention and treatment of infectious diseases................................... Zhenrong Yang,Gangqiao Zhou(950)

Progresses on genetic susceptibility of COVID-19............................................... Yuanfeng Li,Tianzhun Wu,Shunqi Chen,Yuting Wang,Tao Zeng,Ruofan Li,Gangqiao Zhou(963)

Progress on viral and host determinants of influenza A virus species specificity........................................... Tingting Sun,Shan Cen,Jing Wang(976)

Inhibiting pyroptosis: novel immune evasion strategies for pathogens..................................................... Maoyi Yang,Xiaoyue Cui,Shiqi Zheng,Shiyao Ma,Zengzhang Zheng,Wanyan Deng(986)

USP18-mediated protein deISGylation and its role in tuberculosis and other infectious diseases............................................... Qi’ao Zhang,Zilu Wang,Peibo Li,Jianping Xie(998)

Advances in the regulation of inflammasome activation by GBP family in infectious diseases Shuting Quan,Weiwei Jiao,Fang Xu,Lin Sun,Hui Qi,Adong Shen..............................(1007)

Progress on the non-canonical mismatch repair inand its role in antibiotic resistance..................................... Shasha Xiang,Jianping Xie (1018)

Progress on mechanisms of antibiotic resistance in.................. Teng Xu,Haihui Huang(1028)

Research Article

Hsa_circ_0007460 affects the survival of intracellularby regulating autophagy and apoptosis of macrophages......................................... Jinyi Zhang,Yumo He,Jingyu Zhou,Shufeng Weng,Huixia Ma,Taiyue Lin,Ying Xu(1039)

Comparison of clinical and microbiological characteristics of community-acquired hypervirulentliver abscess in diabetic and non-diabetic patients......................................................... Jing Ye,Yuan Wang,Luying Xiong,Yonghong Xiao(1052)

Epidemiololgical and etiological analysis of two clusters of severe fever with thrombocytopenia syndrome.......................... Xin Yang,Yongxiang Wu,Yu Leng,Jiachen Li,Chaojie Wang,Yimei Yuan,Zhen Wang,Lan Zhang,Hao Li,Wei Liu(1062)

Molecular epidemiology and change trend of methicillin-resistantfrom invasive infections of a hospital in Hangzhou from 2012 to 2018..................................... Yunying Zhu,Yuan Wang,Tingting Xiao,Jinru Ji,Ping Shen,Yonghong Xiao(1074)

No. 12

Invited Review

Physiological and pathological mechanisms of oocyte meiosis...................... Zhou Zhou,Qing Sang,Lei Wang(1087)

Review

Progress on the function ofT7SS(ESX) secretion system........... Zhiyong Jiang,Jianping Xie(1100)

Application and prospect of gene chip in genetic breeding of livestock and poultry...................................................... Jiahao Wang,Qingyao Zhao,Yueling Zhou,Liangyu Shi,Chuduan Wang,Ying Yu(1114)

Research Article

Identification and functional study of AA11 family polysaccharide monooxygenase genes in filamentous fungus............................... Wenzhen Du,Yuanjing Li,Jialing Wu,Siyu Chen,Liang Jiang,Gang Liu,Ning Xie(1128)

Analysis of transcriptome differences between subcutaneous and intramuscular adipose tissue of Ningxiang pigs .................................... Fang Wang,Yuebo Zhang,Qian Jiang,Yulong Yin,Bi’e Tan,Jiashun Chen (1147)

Genetics Teaching

Epigenetics comprehensive experimental course based on the integration of science and education to cultivate students' ability of cutting-edge innovation....................................................... Xiufang Ou,Ying Wu,Ning Li,Lili Jiang,Bao Liu,Lei Gong(1158)

（卷終）