国产日韩欧美一区二区三区三州_亚洲少妇熟女av_久久久久亚洲av国产精品_波多野结衣网站一区二区_亚洲欧美色片在线91_国产亚洲精品精品国产优播av_日本一区二区三区波多野结衣 _久久国产av不卡

?

A metastasis map of human cancer cell lines

2021-01-07 23:21:09XinJinetal
四川生理科學(xué)雜志 2021年1期

Xin Jin, et al.

Here we introduce an in vivo barcoding strategy that is capable of determining the metastatic potential of human cancer cell lines in mouse xenografts at scale.We validated the robustness, scalability and reproducibility of the method and applied it to 500 cell lines1,2 spanning 21 types of solid tumour.We created a first-generation metastasis map (MetMap) that reveals organ-specific patterns of metastasis, enabling these patterns to be associated with clinical and genomic features.We demonstrate the utility of MetMap by investigating the molecular basis of breast cancers capable of metastasizing to the brain-a principal cause of death in patients with this type of cancer.Breast cancers capable of metastasizing to the brain showed evidence of altered lipid metabolism.Perturbation of lipid metabolism in these cells curbed brain metastasis development,suggesting a therapeutic strategy to combat the disease and demonstrating the utility of MetMap as a resource to support metastasis research.

诸城市| 阳春市| 碌曲县| 海城市| 买车| 贺州市| 沅陵县| 香河县| 丰顺县| 泾阳县| 社会| 清水河县| 陆川县| 瑞丽市| 深泽县| 城步| 甘谷县| 锦州市| 同江市| 赣州市| 鲁甸县| 安宁市| 威远县| 濮阳市| 屏南县| 泽州县| 沾益县| 宜都市| 吉安县| 阿拉善盟| 营山县| 文水县| 余江县| 南木林县| 鄂托克前旗| 左贡县| 通海县| 措美县| 达孜县| 简阳市| 临清市|