石就家+葉依娜+湯志良

[摘要]目的 分析研究血清淀粉樣蛋白A（SAA）和C-反應(yīng)蛋白（CPR）在小兒感染性疾病鑒別診斷中的應(yīng)用價(jià)值。方法 選取我院2015年3月～2017年2月間收治的小兒感染性疾病患兒500例作為研究對(duì)象，按照其細(xì)菌培養(yǎng)或者病毒鑒別的結(jié)果將其分為細(xì)菌性感染組（293例）和病毒性感染組（207例），分別對(duì)其SAA、CRP等指標(biāo)進(jìn)行檢測(cè)，并取同期接受體檢的健康兒童各200例作為對(duì)照，行相同檢測(cè)，比較各組受檢兒童兩項(xiàng)指標(biāo)檢測(cè)結(jié)果之間的差異。同時(shí)計(jì)算SAA、CRP單獨(dú)或聯(lián)合診斷小兒細(xì)菌性感染性疾病的靈敏度、特異性以及準(zhǔn)確度。結(jié)果 對(duì)各組兒童的SAA和CRP檢測(cè)結(jié)果進(jìn)行比較，均有細(xì)菌性感染組患兒顯著高于病毒性感染組患兒和健康兒童的情況，其中病毒性感染組患兒的SAA顯著高于健康兒童，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。對(duì)SAA、CRP單獨(dú)或聯(lián)合診斷小兒細(xì)菌性感染性疾病的靈敏度、特異性以及準(zhǔn)確度進(jìn)行比較，則有聯(lián)合診斷顯著優(yōu)于SAA或CRP單獨(dú)診斷的效果比較有統(tǒng)計(jì)學(xué)差異（P<0.05）。結(jié)論 聯(lián)合應(yīng)用SAA與CRP對(duì)感染性疾病患兒進(jìn)行診斷，不僅能對(duì)患兒的患病情況進(jìn)行診斷，還能對(duì)細(xì)菌性感染與病毒性感染進(jìn)有效鑒別，操作簡(jiǎn)便易行，特異性俱佳，是一項(xiàng)理想的診斷指標(biāo)。

[關(guān)鍵詞] SAA；CRP；小兒感染性疾病；診斷鑒別

[中圖分類號(hào)] R725 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 2095-0616（2017）20-72-03

Evaluation of combined use of SAA and CRP in the differential diagnosis of infectious diseases in children

SHI Jiujia YE Yi'na TANG Zhiliang

Department of Pediatrics， the Third Peoples Hospital of Nanhai District， Foshan 528244， China

[Abstract] Objective To investigate the value of serum amyloid A（SAA） and C- reactive protein（CPR） in the differential diagnosis of infectious diseases in children. Methods 500 cases children admitted to the pediatric infectious disease was selected as the research object in our hospital between March 2015 and February 2017， they were divided into bacterial infection group（293 cases） and viral infection group（207 cases） according to the identification of the virus or bacteria ， were used to detect the SAA， CRP and other indicators. 200 cases healthy children underwent as control， for the same detection， compared the differences between all groups by the two indicators of child detection results， calculated the sensitivity， specificity and accuracy of SAA and CRP alone or in combination for the diagnosis of bacterial disease in children. Resluts Bacterial infection group with SAA and CRP test results were significantly higher than the group of viral infection children and healthy children， the virus infections SAA test results were significantly higher than in healthy children， the difference was statistically significant（P<0.05）. The sensitivity， specificity and accuracy of combined diagnosis of SAA and CRP in children with bacterial susceptibility diseases were significantly better than those of SAA or CRP， and there was a statistically significant difference between them（P<0.05）. Conclusion The combined application of SAA and CRP for diagnosis of infectious diseases in children， can not only diagnose the prevalence of children， but also to bacterial infection and virus infection in effective identification， simple operation， high specificity， is an ideal diagnostic index.endprint