趙宏艷

【摘?要】 目的：分析阿奇霉素口服與頭孢地嗪靜滴聯(lián)合療法應(yīng)用于小兒急性細(xì)菌痢疾的效果。方法：以2016年2月至2018年2月本院兒科收治的320例急性細(xì)菌型痢疾患兒為研究對象，隨機(jī)分為研究組與對照組各160例。所有患兒給予飲食調(diào)理、糾酸、補(bǔ)液、平衡電解質(zhì)等常規(guī)治療。在此基礎(chǔ)上，對照組患兒給予頭孢曲松鈉針靜滴進(jìn)行抗感染治療;研究組給予阿奇霉素口服聯(lián)合頭孢地嗪靜脈滴注治療。對比兩組患兒臨床治療效果，觀察兩組退熱、止瀉及大便培養(yǎng)轉(zhuǎn)陰等狀況。結(jié)果：治療后，研究組患兒治療總有效率（99.38%）顯著高于對照組（83.13%）（P<0.05）;研究組退熱時間、止瀉時間等指標(biāo)均優(yōu)于對照組（P<0.05）。結(jié)論：將“阿奇霉素口服+頭孢地嗪靜滴聯(lián)合方案”應(yīng)用于臨床小兒急性細(xì)菌型痢疾的治療具有操作簡易、效果顯著、安全可靠等優(yōu)點(diǎn)。

【關(guān)鍵詞】 小兒急性細(xì)菌型痢疾;阿奇霉素;頭孢地嗪

Clinical effect of azithromycin oral and cefodizime intravenous drip in children with acute bacillary dysentery

Zhao Hongyan

Jingbian County Hospital of Chinese Medicine， Yulin， Shaanxi 718500

[Abstract] Objective：To analyze the effect of azithromycin oral combined with Cefodizime intravenous drip in the treatment of acute bacillary dysentery in children. Methods： 320 children with acute bacillary dysentery admitted to our hospital from February 2016 to February 2018 were randomly divided into study group and control group （160 cases each）. The children in the control group were given dietary conditioning， acid rectification， fluid replacement， balanced electrolyte， and corresponding drug treatment for diarrhea and other diseases. On this basis， the study group was given azithromycin orally plus cefodizime intravenous drip for anti-infective treatment. The control group received intravenous drip of ceftriaxone sodium for anti-infection treatment. The effect of clinical treatment was compared between the two groups， and the antipyretic， antidiarrheal and negative change of stool culture were observed in the two groups.Results： After treatment， the total effective rate （99.38%） in the study group was significantly higher than that in the control group （83.13%） with statistical significance （P<0.05）. The indexes of antipyretic time and antidiarrheal time in the study group were better than those in the control group， and the difference was statistically significant （P<0.05）. Conclusion： Azithromycin oral plus cephaladizine intravenous drip combined regimen is simple， effective， safe and reliable in the treatment of acute bacterial dysentery in children.

[Key words]Acute bacillary dysentery in children; Azithromycin; Ceftazidime

小兒急性細(xì)菌性痢疾是一種臨床常見的腸道傳染性疾病，又稱為“菌痢”[1]，多發(fā)于3歲以上兒童，尤其在夏秋季節(jié)發(fā)病率較高。臨床主要伴有發(fā)熱、便血、腹瀉等癥狀，若未進(jìn)行及時有效的治療，病情會迅速發(fā)展。臨床常規(guī)方法治療時間較長且并發(fā)癥較多，不利于患兒病情發(fā)展?；诖?，本文聯(lián)用阿奇霉素口服與頭孢地嗪靜滴，探討聯(lián)合療法應(yīng)用于臨床小兒急性細(xì)菌痢疾的效果?，F(xiàn)將報道整理如下。

1?資料與方法

1.1?一般資料

以2016年2月至2018年2月本院兒科收治的320例急性細(xì)菌性痢疾患兒為研究對象，經(jīng)臨床檢查所有患兒均符合《實(shí)用兒科學(xué)》中關(guān)于菌痢的診斷標(biāo)準(zhǔn)[2]，且病程<5d;臨床主要表現(xiàn)以腹痛、腹瀉、膿血便、黏液便為主;培養(yǎng)糞便可見痢疾桿菌滋長。排除肛裂、腸道息肉、腸套疊等外科疾病及食物過敏、克隆病、結(jié)腸炎等內(nèi)科疾病。以隨機(jī)方式分為研究組與對照組各160例。研究組男性81例，女性79例;對照組男性76例，女性84例。兩組患兒一般資料對比，差異沒有統(tǒng)計學(xué)意義（P>0.05）。